Thermodynamic stability relationship of ternary and binary cocrystals of isoniazid: why pH and coformer concentration matter

Tatiane Cogo Machado, Juliana Rosa and Thiago Caon

CrystEngComm, 2024, 26, 243
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Identification of a previously unreported co-crystal form of acetazolamide: a combination of multiple experimental and virtual screening methods

Alex N. Manin, Ksenia V. Drozd, Artem O. Surov, Andrei V. Churakov, Tatyana V. Volkova and German L. Perlovich

Phys. Chem. Chem. Phys., 2020, 22, 20867
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New insight into improving the solubility of poorly soluble drugs by preventing the formation of their hydrogen-bonds: a case of dapsone salts with camphorsulfonic and 5-sulfosalicylic acid

Yanhui Wu, Xiujia Hao, Jianting Li, Aiying Guan, Zhengzheng Zhou and Fang Guo

CrystEngComm, 2021, 23, 6191
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Two-component molecular crystals: relationship between the entropy term and the molecular volume of co-crystal formation

German L. Perlovich

CrystEngComm, 2018, 20, 3634
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Novel cocrystals of the potent 1,2,4-thiadiazole-based neuroprotector with carboxylic acids: virtual screening, crystal structures and solubility performance

Artem O. Surov, Alexander P. Voronin, Nikita A. Vasilev, Andrey B. Ilyukhin and German L. Perlovich

New J. Chem., 2021, 45, 3034
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Multidrug salt forms of norfloxacin with non-steroidal anti-inflammatory drugs: solubility and membrane permeability studies

Biswajit Bhattacharya, Amit Mondal, Saundray Raj Soni, Susobhan Das, Surojit Bhunia, K. Bal Raju, Animesh Ghosh and C. Malla Reddy

CrystEngComm, 2018, 20, 6420
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Exploring the solubility of novel lamotrigine drug–drug salts: the role of pH and structural variability

Xinyi Yu, Jianting Li, Chenyu Wu, Dezhi Yang, Liang Li, Yang Lu and Zhengzheng Zhou

CrystEngComm, 2025, 27, 820
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Specific features of supramolecular organisation and hydrogen bonding in proline cocrystals: a case study of fenamates and diclofenac

Artem O. Surov, Alexander P. Voronin, Mikhail V. Vener, Andrei V. Churakov and German L. Perlovich

CrystEngComm, 2018, 20, 6970
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Cocrystals of a 1,2,4-thiadiazole-based potent neuroprotector with gallic acid: solubility, thermodynamic stability relationships and formation pathways

Artem O. Surov, Andrei V. Churakov, Alexey N. Proshin, Xia-Lin Dai, Tongbu Lu and German L. Perlovich

Phys. Chem. Chem. Phys., 2018, 20, 14469
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Exploring the Synergistic Effect of Tegafur-Syringic Acid Adduct Against Breast Cancer through DFT Computation, Spectroscopy, Pharmacokinetics and Molecular Docking Simulation

Azar Zochedh, Kaliraj Chandran, Athimoolam Shunmuganarayanan and Asath Bahadur Sultan

Polycyclic Aromatic Compounds, 2024, 44, 2153
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Cocrystal formation, crystal structure, solubility and permeability studies for novel 1,2,4-thiadiazole derivative as a potent neuroprotector

Artem O. Surov, Tatyana V. Volkova, Andrei V. Churakov, Alexey N. Proshin, Irina V. Terekhova and German L. Perlovich

European Journal of Pharmaceutical Sciences, 2017, 109, 31
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Cocrystal Solubility Product Prediction Using an in combo Model and Simulations to Improve Design of Experiments

Alex Avdeef

Pharm Res, 2018, 35
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Cocrystallization of an Antiretroviral Drug Nevirapine: An Eutectic, a Cocrystal Solvate, and a Cocrystal Hydrate

Indumathi Sathisaran and Sameer Vishvanath Dalvi

Crystal Growth & Design, 2021, 21, 2076
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Pharmaceutical cocrystals: from serendipity to design to application

Oisin N. Kavanagh, Denise M. Croker, Gavin M. Walker and Michael J. Zaworotko

Drug Discovery Today, 2019, 24, 796
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Tailoring Chlorthalidone Aqueous Solubility by Cocrystallization: Stability and Dissolution Behavior of a Novel Chlorthalidone-Caffeine Cocrystal

Christian Rodríguez-Ruiz, Pedro Montes-Tolentino, Jorge Guillermo Domínguez-Chávez, Hugo Morales-Rojas, Herbert Höpfl and Dea Herrera-Ruiz

Pharmaceutics, 2022, 14, 334
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Novel Cocrystals and Eutectics of the Antiprotozoal Tinidazole: Mechanochemical Synthesis, Cocrystallization, and Characterization

Octavio E. Fandiño, Lucía Reviglio, Yamila Garro Linck, Gustavo A. Monti, Marina M. Marcos Valdez, Sonia N. Faudone, Mino R. Caira and Norma R. Sperandeo

Crystal Growth & Design, 2020, 20, 2930
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Cocrystal and Coamorphous Solid Forms of Enzalutamide with Saccharin: Structural Characterization and Dissolution Studies

Jupally Prashanth, Ksenia V. Drozd, German L. Perlovich, Sridhar Balasubramanian and Artem Surov

Crystal Growth & Design, 2022, 22, 6703
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Dual-drug co-crystal synthesis for synergistic in vitro effect of three key first-line antiretroviral drugs

Jean B. Ngilirabanga, Paulo P. Rosa, Marique Aucamp, Yunus Kippie and Halima Samsodien

Journal of Drug Delivery Science and Technology, 2020, 60, 101958
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Process Design and Optimization for the Continuous Manufacturing of Nevirapine, an Active Pharmaceutical Ingredient for HIV Treatment

Samir Diab, D. Tyler McQuade, B. Frank Gupton and Dimitrios I. Gerogiorgis

Org. Process Res. Dev., 2019, 23, 320
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Cocrystal solubility product analysis – Dual concentration-pH mass action model not dependent on explicit solubility equations

Alex Avdeef

European Journal of Pharmaceutical Sciences, 2017, 110, 2
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New Pharmaceutical Cocrystal Forms of Flurbiprofen: Structural, Physicochemical, and Thermodynamic Characterization

Artem O. Surov, Alex N. Manin, Alexander P. Voronin, Denis E. Boycov, Oxana V. Magdysyuk and German L. Perlovich

Crystal Growth & Design, 2019, 19, 5751
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Pharmaceutical cocrystals of Efavirenz: Towards the improvement of solubility, dissolution rate and stability

B.H. Jaswanth Gowda, Sunil Kumar Nechipadappu, S.J. Shankar, Murthy Chavali, Karthika Paul, Mohammed Gulzar Ahmed, Sanjana A and Shanthala H.K.

Materials Today: Proceedings, 2022, 51, 394
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Potential Anti-Tumor Drug: Co-Crystal 5-Fluorouracil-nicotinamide

Zhuyan Zhang, Nan Yu, Chang Xue, Shan Gao, Zhaopeng Deng, Min Li, Cong Liu, John Castellot and Siying Han

ACS Omega, 2020, 5, 15777
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Crystal structures and properties of two aromatic carboxylic acid-based medicinal salts of paliperidone

Zheng Shen, Jian Chen, Jilong Ge, Zhuoer Cai, Xiu-Ni Hua and Baiwang Sun

Struct Chem, 2024, 35, 967
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Solid-phase extraction combined with dispersive liquid-liquid microextraction/HPLC-UV as a sensitive and efficient method for extraction, pre-concentration and simultaneous determination of antiretroviral drugs nevirapine, efavirenz and nelfinavir in pharmaceutical formulations and biological samples

Mehregan Safari, Mojtaba Shamsipur, Parvin Zohrabi and Homeira Ebrahimzadeh

Journal of Pharmaceutical and Biomedical Analysis, 2019, 166, 95
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Novel drug-drug salts of enoxacin with enhanced antibacterial activity: Insights from solubility and lipid-water partition coefficient

Jianting Li, Shifang Song, Wanwen Huang, Hongying Fan and Zhengzheng Zhou

Journal of Molecular Liquids, 2023, 385, 122443
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The role of pH and dose/solubility ratio on cocrystal dissolution, drug supersaturation and precipitation

Tatiane Cogo Machado, Gislaine Kuminek, Simone Gonçalves Cardoso and Naír Rodríguez-Hornedo

European Journal of Pharmaceutical Sciences, 2020, 152, 105422
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Pharmaceutical cocrystal and their role in improving solid state properties of active pharmaceutical ingredients

Ameera A Radhi, Iman S Jaafar, Noor S Jaafar and Sarah M Faisal

AJPS, 2023, 23, 180
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Pharmaceutical cocrystals, salts and polymorphs: Advanced characterization techniques

Edyta Pindelska, Agnieszka Sokal and Waclaw Kolodziejski

Advanced Drug Delivery Reviews, 2017, 117, 111
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Tadalafil–Malonic Acid Cocrystal: Physicochemical Characterization, pH-Solubility, and Supersaturation Studies

Manishkumar R. Shimpi, Amani Alhayali, Katie L. Cavanagh, Naír Rodríguez-Hornedo and Sitaram P. Velaga

Crystal Growth & Design, 2018, 18, 4378
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Comparative study of the cocrystals with layered/cavity structure in regulating in vitro pharmaceutical properties of diuretic acetazolamide

Guang-Yao Bai, Zhi-Yong Wu, Jin-Lei Xing and Yan-Tuan Li

Journal of Molecular Structure, 2023, 1271, 134035
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Virtual Screening, Structural Analysis, and Formation Thermodynamics of Carbamazepine Cocrystals

Artem O. Surov, Anna G. Ramazanova, Alexander P. Voronin, Ksenia V. Drozd, Andrei V. Churakov and German L. Perlovich

Pharmaceutics, 2023, 15, 836
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New Cocrystals of Hydrochlorothiazide: Optimizing Solubility and Membrane Diffusivity

Shanmukha Prasad Gopi, Manas Banik and Gautam R. Desiraju

Crystal Growth & Design, 2017, 17, 308
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Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

Steven A. Ross, Andrew P. Hurt, Milan Antonijevic, Nicolaos Bouropoulos, Adam Ward, Pat Basford, Mark McAllister and Dennis Douroumis

Pharmaceutics, 2021, 13, 419
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Predicting the Effect of pH on Stability and Solubility of Polymorphs, Hydrates, and Cocrystals

Linda Lange, Miko Schleinitz and Gabriele Sadowski

Crystal Growth & Design, 2016, 16, 4136
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Multidrug Cocrystal of Anticonvulsants: Influence of Strong Intermolecular Interactions on Physiochemical Properties

Ramanpreet Kaur, Katie L. Cavanagh, Naír Rodríguez-Hornedo and Adam J. Matzger

Crystal Growth & Design, 2017, 17, 5012
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Posaconazole Cocrystal with Superior Solubility and Dissolution Behavior

Gislaine Kuminek, Katie L. Cavanagh, M. Fátima M. da Piedade and Naír Rodríguez-Hornedo

Crystal Growth & Design, 2019, 19, 6592
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High-throughput chemometrically assisted flow-injection method for the simultaneous determination of multi-antiretrovirals in water

Lesly Paradina Fernández, Romina Brasca, Mirta R. Alcaráz and María J. Culzoni

Microchemical Journal, 2018, 141, 80
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Pharmaceutical Cocrystals: Formulation Approaches to Develop Robust Drug Products

Naga Kiran Duggirala, Shawn M. LaCasse, Michael J. Zaworotko, Joseph F. Krzyzaniak and Kapildev K. Arora

Crystal Growth & Design, 2020, 20, 617
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A Review of Pharmaceutical Nano-Cocrystals: A Novel Strategy to Improve the Chemical and Physical Properties for Poorly Soluble Drugs

Jianbing Tan, Jianhao Liu and Liling Ran

Crystals, 2021, 11, 463
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Mitigating Punch Sticking Propensity of Celecoxib by Cocrystallization: An Integrated Computational and Experimental Approach

Chenguang Wang, Shubhajit Paul, David J. Sun, Sten O. Nilsson Lill and Changquan Calvin Sun

Crystal Growth & Design, 2020, 20, 4217
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Cocrystals Mitigate Negative Effects of High pH on Solubility and Dissolution of a Basic Drug

Yitian M. Chen and Naír Rodríguez-Hornedo

Crystal Growth & Design, 2018, 18, 1358
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Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility

Nikita A. Vasilev, Artem O. Surov, Alexander P. Voronin, Ksenia V. Drozd and German L. Perlovich

International Journal of Pharmaceutics, 2021, 599, 120441
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Cocrystals to facilitate delivery of poorly soluble compounds beyond-rule-of-5

Gislaine Kuminek, Fengjuan Cao, Alanny Bahia de Oliveira da Rocha, Simone Gonçalves Cardoso and Naír Rodríguez-Hornedo

Advanced Drug Delivery Reviews, 2016, 101, 143
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New Multicomponent Forms of the Antiretroviral Nevirapine with Improved Dissolution Performance

Rogeria N. Costa, Ana L. Reviglio, Sana Siedler, Simone G. Cardoso, Yamila G. Linck, Gustavo A. Monti, Alexandre M. G. Carvalho, Jackson A. L. C. Resende, Marcelo H. C. Chaves, Helvécio V. A. Rocha, Duane Choquesillo-Lazarte, Lourdes Infantes and Silvia L. Cuffini

Crystal Growth & Design, 2020, 20, 688
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Understanding the Differences Between Cocrystal and Salt Aqueous Solubilities

Katie L. Cavanagh, Chinmay Maheshwari and Naír Rodríguez-Hornedo

Journal of Pharmaceutical Sciences, 2018, 107, 113
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Mechanistic Basis of Cocrystal Dissolution Advantage

Fengjuan Cao, Gordon L. Amidon, Naír Rodríguez-Hornedo and Gregory E. Amidon

Journal of Pharmaceutical Sciences, 2018, 107, 380
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Extending the Range of Nitrofurantoin Solid Forms: Effect of Molecular and Crystal Structure on Formation Thermodynamics and Physicochemical Properties

Artem O. Surov, Alexander P. Voronin, Ksenia V. Drozd, Tatyana V. Volkova, Nikita Vasilev, Dmitriy Batov, Andrei V. Churakov and German L. Perlovich

Crystal Growth & Design, 2022, 22, 2569
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Characterization of systems with amino-acids and oligosaccharides as modifiers of biopharmaceutical properties of furosemide

Julieta Abraham Miranda, Claudia Garnero, Ariana Zoppi, Vanesa Sterren, Alejandro P. Ayala and Marcela R. Longhi

Journal of Pharmaceutical and Biomedical Analysis, 2018, 149, 143
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Discovery of Cilnidipine Cocrystals with Enhanced Dissolution by the Use of Computational Tools and Semiautomatic High-Throughput Screening

Matteo Guidetti, Rolf Hilfiker, Susan M. De Paul, Annette Bauer-Brandl, Fritz Blatter and Martin Kuentz

Crystal Growth & Design, 2025, 25, 3374
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Isoniazid-Resveratrol Cocrystal: A Novel Alternative for Topical Treatment of Cutaneous Tuberculosis

Juliana Rosa, Tatiane Cogo Machado, Ana Karolina da Silva, Gislaine Kuminek, Adailton João Bortolluzzi, Thiago Caon and Simone Gonçalves Cardoso

Crystal Growth & Design, 2019, 19, 5029
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Continuous, one-step synthesis of pharmaceutical cocrystals via hot melt extrusion from neat to matrix-assisted processing – State of the art

Maciej Gajda, Karol P. Nartowski, Janusz Pluta and Bożena Karolewicz

International Journal of Pharmaceutics, 2019, 558, 426
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Cocrystals of Fluconazole with Aromatic Carboxylic Acids: Competition between Anhydrous and Hydrated Solid Forms

Artem O. Surov, Alexander P. Voronin, Nikita A. Vasilev, Andrei V. Churakov and German L. Perlovich

Crystal Growth & Design, 2020, 20, 1218
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