Issue 9, 2022

Lab on a chip devices for fertility: from proof-of-concept to clinical impact

Abstract

Microfluidics offers tremendous opportunities to understand the underlying biology of fertilization at the single-cell level and improve infertility management, however, its true clinical impact is yet to be realized. Lab-on-a-chip devices have generally failed to diffuse into clinical practice due to issues associated with their translation or their practicality and performance in clinical settings. In this perspective, I reflect on how the full potential of microfluidic technologies for fertility can be realized by considering regulatory and manufacturing considerations at the development stage and by redefining our developmental goals to directly target the ultimate clinical needs. I also challenge the common rationale around developing technologies for infertility treatment based on reducing cost and complexity in operation as the ultimate outcome is invaluable, human life.

Graphical abstract: Lab on a chip devices for fertility: from proof-of-concept to clinical impact

Article information

Article type
Perspective
Submitted
17 Dis 2021
Accepted
06 Eph 2022
First published
07 Eph 2022

Lab Chip, 2022,22, 1680-1689

Lab on a chip devices for fertility: from proof-of-concept to clinical impact

R. Nosrati, Lab Chip, 2022, 22, 1680 DOI: 10.1039/D1LC01144H

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