Issue 43, 2019

Liquid biopsy in combination with solid-state electrochemical sensors and nucleic acid amplification

Abstract

Solid-state electrochemical sensors are developing as a new platform for liquid biopsy, combining detection and analysis of nucleic acids with isothermal nucleic acid amplification reactions. For the detection of small nucleic acids such as cfDNA, ctDNA and miRNA in liquid biopsy, further development of highly sensitive and precise devices is required to transcend the barrier of classical detection technology. Electrochemical sensors based on engineering approaches are advantageous for miniaturization of systems and convenience of diagnosis, and the analysis of data obtained with these sensors dovetails with transition to an information society. This review briefly surveys the current development of electrochemical sensors combined with isothermal amplification for nucleic acid detection and predicts the future direction of research.

Graphical abstract: Liquid biopsy in combination with solid-state electrochemical sensors and nucleic acid amplification

Article information

Article type
Review Article
Submitted
15 Eph 2019
Accepted
21 Aga 2019
First published
06 Sep 2019

J. Mater. Chem. B, 2019,7, 6655-6669

Author version available

Liquid biopsy in combination with solid-state electrochemical sensors and nucleic acid amplification

M. Tabata and Y. Miyahara, J. Mater. Chem. B, 2019, 7, 6655 DOI: 10.1039/C9TB00718K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements