Issue 73, 2019

Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

Abstract

A simple, mild and efficient approach to access fluorinated dibenz[b,e]azepines via visible-light photoredox catalysis is presented. Inexpensive and commercially available fluoroalkyl anhydrides in concert with pyridine N-oxide are employed as the source of the fluoroalkyl radicals. A one-pot process involving the trifluoroacetylation of unprotected secondary benzyl amines followed by radical cyclization could also afford the desired fluorinated dibenz[b,e]azepines.

Graphical abstract: Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

Supplementary files

Article information

Article type
Communication
Submitted
28 Jun 2019
Accepted
12 Aga 2019
First published
12 Aga 2019

Chem. Commun., 2019,55, 10848-10851

Photoinduced synthesis of fluorinated dibenz[b,e]azepines via radical triggered cyclization

X. Qi, H. Zhang, Z. Pan, R. Liang, C. Zhu, J. Li, Q. Tong, X. Gao, L. Wu and J. Zhong, Chem. Commun., 2019, 55, 10848 DOI: 10.1039/C9CC04977K

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