Issue 42, 2013

Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(i) site that is resistant to O2 oxidation

Abstract

Copper coordination to soluble oligomers of the English (AβH(6)R) mutant of the amyloid-β peptide is probed. Cu(II) coordination yields a square planar (N/O)4 coordination environment, while reduction yields an O2 inert linear bis-His Cu(I) centre.

Graphical abstract: Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(i) site that is resistant to O2 oxidation

Supplementary files

Article information

Article type
Communication
Submitted
15 Jan 2013
Accepted
15 Eph 2013
First published
23 Eph 2013

Chem. Commun., 2013,49, 4797-4799

Copper ligation to soluble oligomers of the English mutant of the amyloid-β peptide yields a linear Cu(I) site that is resistant to O2 oxidation

K. L. Peck, H. S. Clewett, J. C. Schmitt and J. Shearer, Chem. Commun., 2013, 49, 4797 DOI: 10.1039/C3CC40326B

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