Issue 28, 2011

In vivo cell death mediated by synthetic ion channels

Abstract

Synthetic ion channel hydraphiles, which are known to infiltrate membranes and disrupt ion homeostasis, were tested as direct injection toxins in live mice as potential schlerotic agents. The study uses a near-IR dye to image and evaluate the success of the approach.

Graphical abstract: In vivo cell death mediated by synthetic ion channels

Supplementary files

Article information

Article type
Communication
Submitted
18 Mey 2011
Accepted
30 Mey 2011
First published
17 Jun 2011

Chem. Commun., 2011,47, 7977-7979

In vivo cell death mediated by synthetic ion channels

B. A. Smith, M. M. Daschbach, S. T. Gammon, S. Xiao, S. E. Chapman, C. Hudson, M. Suckow, D. Piwnica-Worms, G. W. Gokel and W. M. Leevy, Chem. Commun., 2011, 47, 7977 DOI: 10.1039/C1CC12933C

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