Issue 17, 2002
From the journal:

Chemical Communications

Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

Martyn Frederickson,a   John R. Cogginsb  and  Chris Abell*a  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ca26@cam.ac.uk

b Division of Biochemistry and Molecular Biology, IBLS, Glasgow University, Glasgow, UK

Abstract

A vinyl fluoride analogue of the intermediate in the reaction catalysed by type II dehydroquinase enzymes has been synthesized over seven steps from (−)-quinic acid and shown to be a potent enzyme inhibitor.

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B205105M
Article type
Communication
Submitted
27 Mey 2002
Accepted
08 Jul 2002
First published
26 Jul 2002

Chem. Commun., 2002, 1886-1887

Permissions

Request permissions

Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

M. Frederickson, J. R. Coggins and C. Abell, Chem. Commun., 2002, 1886 DOI: 10.1039/B205105M

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements