Issue 46, 2023

Conducting polymer-based scaffolds for neuronal tissue engineering

Abstract

Neuronal tissue engineering has immense potential for treating neurological disorders and facilitating nerve regeneration. Conducting polymers (CPs) have emerged as a promising class of materials owing to their unique electrical conductivity and biocompatibility. CPs, such as poly(3,4-ethylenedioxythiophene) (PEDOT), poly(3-hexylthiophene) (P3HT), polypyrrole (PPy), and polyaniline (PANi), have been extensively explored for their ability to provide electrical cues to neural cells. These polymers are widely used in various forms, including porous scaffolds, hydrogels, and nanofibers, and offer an ideal platform for promoting cell adhesion, differentiation, and axonal outgrowth. CP-based scaffolds can also serve as drug delivery systems, enabling localized and controlled release of neurotrophic factors and therapeutic agents to enhance neural regeneration and repair. CP-based scaffolds have demonstrated improved neural regeneration, both in vitro and in vivo, for treating spinal cord and peripheral nerve injuries. In this review, we discuss synthesis and scaffold processing methods for CPs and their applications in neuronal tissue regeneration. We focused on a detailed literature review of the central and peripheral nervous systems.

Graphical abstract: Conducting polymer-based scaffolds for neuronal tissue engineering

Article information

Article type
Review Article
Submitted
13 Aga 2023
Accepted
27 Okt 2023
First published
13 Nov 2023

J. Mater. Chem. B, 2023,11, 11006-11023

Conducting polymer-based scaffolds for neuronal tissue engineering

H. Yi, R. Patel, K. D. Patel, Louis-S. Bouchard, A. Jha, A. W. Perriman and M. Patel, J. Mater. Chem. B, 2023, 11, 11006 DOI: 10.1039/D3TB01838E

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