Issue 11, 2022

Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

Abstract

A general, safe and scalable reductive protocol, based on the in situ generation of H2 from aluminum and water, has been developed in deep eutectic solvents for the reduction of many organic compounds under Pd-catalysis. The methodology has been efficiently applied to the multigram-scale synthesis of benzindopyrine as an active pharmaceutical ingredient.

Graphical abstract: Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

Supplementary files

Article information

Article type
Communication
Submitted
16 Feb 2022
Accepted
28 Eph 2022
First published
03 Mey 2022

Green Chem., 2022,24, 4388-4394

Deep eutectic solvents meet safe, scalable and sustainable hydrogenations enabled by aluminum powder and Pd/C

F. Messa, G. Dilauro, A. N. Paparella, L. Silvestri, G. Furlotti, T. Iacoangeli, S. Perrone and A. Salomone, Green Chem., 2022, 24, 4388 DOI: 10.1039/D2GC00636G

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