Issue 13, 2021
From the journal:

Nanoscale

Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis†

Weiwei Zhao,a   Hua Wang,b   Haimang Wang,a   Ying Han,a   Zhibo Zheng,c   Xudong Liu,d   Bin Feng*e  and  Hongyu Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China
E-mail: zhanghyu@tsinghua.edu.cn

b Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China

c Department of International Medical Services, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

d Medical Science Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

e Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China

Abstract

Visible light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement were constructed by supramolecular interaction between azobenzene-modified mesoporous silica nanoparticles (bMSNs-AZO) and β-cyclodextrin-modified poly(2-methacryloyloxyethyl phosphorylcholine) (CD-PMPC). Visible light could effectively trigger azobenzene isomerization and thus induce drug release after passing through the dermal tissue. Additionally, the hydration layer formed by CD-PMPC on the surface of the nanoparticles played an important role in lubrication enhancement, which was beneficial for the treatment of osteoarthritis.

Graphical abstract: Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

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Article information

DOI
https://doi.org/10.1039/D0NR08887K
Article type
Communication
Submitted
16 Dis 2020
Accepted
19 Feb 2021
First published
20 Feb 2021

Nanoscale, 2021,13, 6394-6399

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Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis

W. Zhao, H. Wang, H. Wang, Y. Han, Z. Zheng, X. Liu, B. Feng and H. Zhang, Nanoscale, 2021, 13, 6394 DOI: 10.1039/D0NR08887K

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