Issue 45, 2020

Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia

Abstract

We report two highly fluorinated Cu-based imaging agents, CuL1 and CuL2, for detecting cellular hypoxia as nanoemulsion formulations. Both complexes retained their initial quenched 19F MR signals due to paramagnetic Cu2+; however, both complexes displayed a large signal increase when the complex was reduced. DLS studies showed that the CuL1 nanoemulsion (NECuL1) had a hydrodiameter of approximately 100 nm and that it was stable for four weeks post-preparation. Hypoxic cells incubated with NECuL1 showed that 40% of the Cu2+ taken up was reduced in low oxygen environments.

Graphical abstract: Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia

Supplementary files

Article information

Article type
Paper
Submitted
29 Mas 2020
Accepted
15 Jul 2020
First published
16 Jul 2020

Dalton Trans., 2020,49, 16419-16424

Author version available

Responsive fluorinated nanoemulsions for 19F magnetic resonance detection of cellular hypoxia

R. T. Kadakia, D. Xie, H. Guo, B. Bouley, M. Yu and E. L. Que, Dalton Trans., 2020, 49, 16419 DOI: 10.1039/D0DT01182G

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