Issue 17, 2018

Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging

Abstract

Fluorescent organic nanoparticles based on small molecules have emerged as an attractive class of fluorescent agents for bioimaging in recent years. Herein, we report orange light-emitting BTPEBD based organic nanoparticles (BTPEBD NPs) with a large Stokes shift (>135 nm), ultrahigh quantum yield (>90% in water) and aggregation-induced emission characteristics. Single nanoparticle analysis studied by wide field microscopy imaging further proves that the BTPEBD NPs exhibit high brightness and good photostability. Both in vitro and in vivo experiments reveal that the BTPEBD NPs are promising fluorescent agents for cellular imaging and real-time two-photon lung vasculature imaging.

Graphical abstract: Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging

Article information

Article type
Paper
Submitted
08 Feb 2018
Accepted
03 Eph 2018
First published
11 Eph 2018

J. Mater. Chem. B, 2018,6, 2630-2636

Organic nanoparticles with ultrahigh quantum yield and aggregation-induced emission characteristics for cellular imaging and real-time two-photon lung vasculature imaging

J. Liu, M. Evrard, X. Cai, G. Feng, N. Tomczak, L. G. Ng and B. Liu, J. Mater. Chem. B, 2018, 6, 2630 DOI: 10.1039/C8TB00386F

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