A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

Liyun Zhang; Jun Cheng Er; Hao Jiang; Xin Li; Zhaofeng Luo; Thomas Ramezani; Yi Feng; Mui Kee Tang; Young-Tae Chang; Marc Vendrell

doi:10.1039/C6CC00095A

A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase†

Liyun Zhang,‡*^a Jun Cheng Er,‡^bc Hao Jiang,^d Xin Li,^a Zhaofeng Luo,^d Thomas Ramezani,^e Yi Feng,^e Mui Kee Tang,^b Young-Tae Chang^b and Marc Vendrell*^e

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* Corresponding authors

^a Institute of Technical Biology and Agriculture Engineering, Key Laboratory of Ion Beam Bioengineering, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, P. R. China
E-mail: zly0605@ustc.edu.cn

^b Department of Chemistry, National University of Singapore, 3 Science Drive 2, Singapore

^c Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences, #05-01, 28 Medical Drive, 117456 Singapore

^d School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P. R. China

^e MRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, EH16 4TJ Edinburgh, UK
E-mail: mvendrel@staffmail.ed.ac.uk

Abstract

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

This article is part of the themed collection: 2016 Emerging Investigators

Chemical Communications

A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase†

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A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase

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