Issue 23, 2011

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

Abstract

A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeCvia a hybridisation sensing assay.

Graphical abstract: Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

Supplementary files

Article information

Article type
Communication
Submitted
28 Feb 2011
Accepted
19 Eph 2011
First published
12 Mey 2011

Chem. Commun., 2011,47, 6629-6631

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

J. H. A. Duprey, Z. Zhao, D. M. Bassani, J. Manchester, J. S. Vyle and J. H. R. Tucker, Chem. Commun., 2011, 47, 6629 DOI: 10.1039/C1CC11205H

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