Issue 17, 2002

Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

Abstract

A vinyl fluoride analogue of the intermediate in the reaction catalysed by type II dehydroquinase enzymes has been synthesized over seven steps from (−)-quinic acid and shown to be a potent enzyme inhibitor.

Supplementary files

Article information

Article type
Communication
Submitted
27 Mey 2002
Accepted
08 Jul 2002
First published
26 Jul 2002

Chem. Commun., 2002, 1886-1887

Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases

M. Frederickson, J. R. Coggins and C. Abell, Chem. Commun., 2002, 1886 DOI: 10.1039/B205105M

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