Issue 76, 2024

Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

Abstract

Separation of racemic drugs is of great importance and interest in chemistry and pharmacology. Here, we report the bottom-up synthesis of the binaphthyl-based chiral covalent organic frameworks (CCOFs), (R)-BHTP-COF. Then, high-performance liquid chromatography (HPLC) columns were prepared using (R)-BHTP-COF as a chiral stationary phase (CSP). Racemic ibuprofen was successfully baseline-separated on (R)-BHTP-COF-based CSP, and achieved excellent selectivity (α = 2.32) and chromatographic resolution (Rs = 3.39) factors. Meanwhile, the separation of six racemic drugs by the (R)-BHTP-COF-packed column exhibited high resolution, selectivity, and durability. The successful applications indicate the great potential of CCOFs as a novel stationary phase for efficient HPLC separation.

Graphical abstract: Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

Supplementary files

Article information

Article type
Communication
Submitted
27 Eph 2024
Accepted
16 Jul 2024
First published
05 Sep 2024

Chem. Commun., 2024,60, 10580-10583

Binaphthyl-based chiral covalent organic frameworks for chiral drug separation

H. Ma, H. Jiang, Z. Yao, J. Tan, Y. Xing, G. Chen and Y. Dong, Chem. Commun., 2024, 60, 10580 DOI: 10.1039/D4CC02028F

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