Issue 37, 2023

Fe(iii)-incorporated porphyrin-based conjugated organic polymer as a peroxidase mimic for the sensitive determination of glucose and H2O2

Abstract

Nanozymes, i.e., nanomaterials that possess intrinsic enzyme-like behaviour, have thrived over the past few decades owing to their advantages of superior stability and effortless storage. Such artificial enzymes can be a perfect alternative to naturally occurring enzymes, which have disadvantages of high cost and limited functionality. In this work, we present the fabrication of an Fe(III)-incorporated porphyrin-based conjugated organic polymer as a nanozyme for the efficient detection of glucose through its intrinsic peroxidase activity and the amperometric detection of hydrogen peroxide. The iron-incorporated porphyrin-based conjugated organic polymer (Fe-DMP-POR) possesses a spherical morphology with high chemical and thermal stability. Exploiting the peroxidase-mimicking activity of the material for the determination of glucose, a detection limit of 4.84 μM is achieved with a linear range of 0–0.15 mM. The Fe-DMP-POR also exhibits a reasonable recovery range for the detection of human blood glucose. The as-synthesized material can also act as an H2O2 sensor, with a sensitivity of 947.67 μA cm−2 mM−1 and a limit of detection of 3.16 μM.

Graphical abstract: Fe(iii)-incorporated porphyrin-based conjugated organic polymer as a peroxidase mimic for the sensitive determination of glucose and H2O2

Supplementary files

Article information

Article type
Paper
Submitted
30 Eph 2023
Accepted
21 Aga 2023
First published
22 Aga 2023

J. Mater. Chem. B, 2023,11, 8956-8965

Fe(III)-incorporated porphyrin-based conjugated organic polymer as a peroxidase mimic for the sensitive determination of glucose and H2O2

S. N. Bhaduri, D. Ghosh, S. Chatterjee, R. Biswas, A. Bhaumik and P. Biswas, J. Mater. Chem. B, 2023, 11, 8956 DOI: 10.1039/D3TB00977G

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