Issue 21, 2020

Chalcogen effects on the primary antioxidant activity of chrysin and quercetin

Abstract

The effect of chalcogens on the scavenging power of chrysin and quercetin antioxidants against peroxyl radicals has been investigated in lipid and aqueous solutions, using the density functional theory. Different mechanisms and reaction sites were considered as well as different acid–base species in aqueous solutions. It was found that the polarity of the environment plays an important role in their reactivity towards peroxyl radicals, which is predicted to be significantly higher in aqueous solution than in the lipid medium. The effect of replacing oxygen for sulfur or selenium was found to be more significant for chrysin than for quercetin, mainly because chrysin is a poor hydroperoxyl radical scavenger, while quercetin is very efficient for this purpose. In the case of chrysin, the selenium derivative is predicted to be a very potent peroxyl scavenger, both in aqueous and lipid media. The three members of the quercetin family, on the other hand, are exceptionally good for scavenging HOO˙ in aqueous solution, at physiological pH, with rate constants being within the diffusion-limited regime. In the lipid medium, the sulfur derivative (SQ) is predicted to be the most efficient one, with rate constants in the order of 104 M−1 s−1. Regarding the influence of pH, for chrysin and its derivatives, the higher the pH the faster the reaction with HOO˙, while quercetin and its analogs are predicted to exhibit their maximum peroxyl radical scavenging activity at pH values from 7 to 10.

Graphical abstract: Chalcogen effects on the primary antioxidant activity of chrysin and quercetin

Supplementary files

Article information

Article type
Paper
Submitted
10 Eph 2020
Accepted
07 Mey 2020
First published
11 Mey 2020

New J. Chem., 2020,44, 9073-9082

Chalcogen effects on the primary antioxidant activity of chrysin and quercetin

R. Castañeda-Arriaga, T. Marino, N. Russo, J. R. Alvarez-Idaboy and A. Galano, New J. Chem., 2020, 44, 9073 DOI: 10.1039/D0NJ01795G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements