Issue 24, 2018

An easy-to-fabricate clearable CuS-superstructure-based multifunctional theranostic platform for efficient imaging guided chemo-photothermal therapy

Abstract

Despite drug delivery systems (DDSs) receiving ever-increasing attention, development of a simple, effective, sensitive and clearable drug delivery and multifunctional theranostic nanoplatform for cancer therapy is still highly desirable and remains a challenge. Herein, using a one-step solvothermal method, hollow acanthosphere-like CuS superstructures assembled from ∼10 nm nanoparticles (NPs) were successfully obtained and used as an efficient drug delivery and theranostic platform for photoacoustic (PA) and infrared (IR) thermal imaging-guided cancer combination therapy. The special hollow characteristic of CuS superstructures with mesoporous shells and large cavities grants them high drug loading capacity; they demonstrate near-infrared (NIR)/pH stimuli-sensitive drug release and pronounced synergetic effects of chemo-photothermal therapy both in vitro and in vivo. In particular, our as-fabricated hollow loose CuS superstructures, with easily breakable characteristic, are biodegradable and able to be cleared from the body when their therapy task is completed. This CuS-superstructure-based clearable drug delivery and “all-in-one” cancer theranostic platform might provide possibilities for improving therapeutic efficacy and minimizing adverse effects.

Graphical abstract: An easy-to-fabricate clearable CuS-superstructure-based multifunctional theranostic platform for efficient imaging guided chemo-photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
21 Eph 2018
Accepted
19 Mey 2018
First published
22 Mey 2018

Nanoscale, 2018,10, 11430-11440

An easy-to-fabricate clearable CuS-superstructure-based multifunctional theranostic platform for efficient imaging guided chemo-photothermal therapy

W. Zhang, J. Xiao, Q. Cao, W. Wang, X. Peng, G. Guan, Z. Cui, Y. Zhang, S. Wang, R. Zou, X. Wan, H. Qiu and J. Hu, Nanoscale, 2018, 10, 11430 DOI: 10.1039/C8NR03271H

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