Issue 50, 2018

Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

Abstract

Herein a novel, elusive cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes is reported. Taking advantage of the intramolecular cyano migration strategy, the reaction proceeds stereoselectively to deliver E-olefinic products. A variety of tetrasubstituted trifluoromethylthiolated acrylonitriles are afforded in modest to good yields.

Graphical abstract: Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

Supplementary files

Article information

Article type
Communication
Submitted
10 Feb 2018
Accepted
20 Mas 2018
First published
20 Mas 2018

Chem. Commun., 2018,54, 6812-6815

Cyanotrifluoromethylthiolation of unactivated dialkyl-substituted alkynes via cyano migration: synthesis of trifluoromethylthiolated acrylonitriles

M. Ji, J. Yu and C. Zhu, Chem. Commun., 2018, 54, 6812 DOI: 10.1039/C8CC01189C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements