Issue 54, 2016

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

Abstract

[18F]FMTEB, [18F]FPEB, [18F]flumazenil, [18F]DAA1106, [18F]MFBG, [18F]FDOPA, [18F]FMT and [18F]FDA are prepared from the corresponding arylboronic esters and [18F]KF/K222 in the presence of Cu(OTf)2py4. The method was successfully applied using three radiosynthetic platforms, and up to 26 GBq of non-carrier added starting activity of 18F-fluoride.

Graphical abstract: Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

Supplementary files

Article information

Article type
Communication
Submitted
19 Eph 2016
Accepted
23 Mey 2016
First published
23 Mey 2016

Chem. Commun., 2016,52, 8361-8364

Enhanced copper-mediated 18F-fluorination of aryl boronic esters provides eight radiotracers for PET applications

S. Preshlock, S. Calderwood, S. Verhoog, M. Tredwell, M. Huiban, A. Hienzsch, S. Gruber, T. C. Wilson, N. J. Taylor, T. Cailly, M. Schedler, T. L. Collier, J. Passchier, R. Smits, J. Mollitor, A. Hoepping, M. Mueller, C. Genicot, J. Mercier and V. Gouverneur, Chem. Commun., 2016, 52, 8361 DOI: 10.1039/C6CC03295H

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