Issue 46, 2016

Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

Abstract

A new method of inducing the crystallisation of metastable polymorphs by isomorphous templating has been developed and used to reproduce the crystallisation of CBZ-V on the surface of DHC-II. Studies of the growth of CBZ-V on DHC-II single crystals show crystals growing laterally and vertically on DHC-II surfaces without any significant face selectivity. The generality of this computationally inspired crystallisation approach is demonstrated by producing the first crystals of an entirely new polymorph of cyheptamide, which is isomorphous to both DHC-II and CBZ-V.

Graphical abstract: Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

Supplementary files

Article information

Article type
Communication
Submitted
25 Feb 2016
Accepted
05 Mey 2016
First published
05 Mey 2016

Chem. Commun., 2016,52, 7384-7386

Isomorphous template induced crystallisation: a robust method for the targeted crystallisation of computationally predicted metastable polymorphs

V. K. Srirambhatla, R. Guo, S. L. Price and A. J. Florence, Chem. Commun., 2016, 52, 7384 DOI: 10.1039/C6CC01710J

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