Issue 23, 2011
From the journal:

Chemical Communications

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe†‡

Jean-Louis H. A. Duprey,a   Zheng-yun Zhao,a   Dario M. Bassani,b   Jack Manchester,a   Joseph S. Vylec  and  James H. R. Tucker*a  

* Corresponding authors

a School of Chemistry, University of Birmingham, Edgbaston, Birmingham, UK
E-mail: j.tucker@bham.ac.uk
Fax: +44 (0)121 414 4403
Tel: +44 (0)121 414 4422

b Institut des Sciences Moléculaires, CNRS UMR 5255, Université Bordeaux 1, 351 Cours de la Libération, F-33405 Talence, France
E-mail: d.bassani@ism.u-bordeaux1.fr
Fax: +33 (0)5 4000 6158
Tel: +33 (0)5 4000 2827

c School of Chemistry and Chemical Engineering, David Keir Building, Queen's University Belfast (QUB), Stranmillis Rd, Belfast BT9 5AG, UK
E-mail: j.vyle@qub.ac.uk
Fax: +44 (0)28 9097 6524
Tel: +44 (0)28 9097 548

Abstract

A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeCvia a hybridisation sensing assay.

Graphical abstract: Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

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Article information

DOI
https://doi.org/10.1039/C1CC11205H
Article type
Communication
Submitted
28 Feb 2011
Accepted
19 Eph 2011
First published
12 Mey 2011

Chem. Commun., 2011,47, 6629-6631

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Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe

J. H. A. Duprey, Z. Zhao, D. M. Bassani, J. Manchester, J. S. Vyle and J. H. R. Tucker, Chem. Commun., 2011, 47, 6629 DOI: 10.1039/C1CC11205H

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