Saurav Kumar, Jiewei Jiang, Mia S. Donald-Paladino, Joy Chen, Andrea Gutierrez, Alexander J. Federation, Frank Szulzewsky, Eric C. Holland, Fleur M. Ferguson and Behnam Nabet
RSC Chem. Biol., 2026,7, 596-614
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RSC Chemical Biology Emerging Investigators 2026
Abstract
JWJ-01-378 recruits cereblon (CRBN) to induce potent and selective degradation of oncogenic TRK fusions, leading to a collapse in signaling and loss of cancer cell viability. Graphic was created using https://biorender.com.
Anjie S. Bispat, Fernanda C. Cardoso, Md. Mahadhi Hasan, Yashad Dongol, Ricki Wilcox, Richard J. Lewis, Peter J. Duggan and Kellie L. Tuck
RSC Med. Chem., 2024,15, 916-936
Abstract
A detailed SAR study led to two potent CaV2.2 inhibitors, the sulfonamide derivatives 42 and 45, which showed high plasma stability, low toxicity, favourable CNS MPO scores (4.0–4.4), and strong potency.
Younghoon Kim, Jaewon Song, Namkyoung Kim and Taebo Sim
RSC Med. Chem., 2025,16, 2314-2359
From themed collection:
Articles behind our 2025 journal covers
Abstract
Small-molecule and antibody-based targeted therapies for intrahepatic cholangiocarcinoma (iCCA): addressing promising oncogenic molecular alterations, including IDH1, FGFR2, BRAF, HER2, and the PD-1/PD-L1 axis.
M. Shaheer Malik, Hossa F. Alshareef, Khalid A. Alfaidi, Hissana Ather, Zainularifeen Abduljaleel, Essam M. Hussein, Ziad Moussa and Saleh A. Ahmed
RSC Adv., 2024,14, 3972-3984
From themed collection:
2024 Reviews in RSC Advances
Abstract
Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines.
Nádia R. Senhorães, Bruna F. Silva, Raquel Sousa, Bruna P. Leite, Jorge M. Gonçalves, Filipe A. Almeida Paz, Cristina Pereira-Wilson and Alice M. Dias
Org. Biomol. Chem., 2024,22, 1500-1513
Abstract
Novel 6,8-diaminopurines were synthesized using a fast cascade reaction from easily accessible 5-aminoimidazole precursors. Preliminary assessments suggest that the new entities are excellent candidates for further development as anticancer agents.