Polydosetins & pullularins—bioactive tetramic acids & cyclodepsipeptides from the endophytic and nematophagous fungus Polydomus karssenii

Natalia A. Llanos-López, Jan-Peer Wennrich, Janette Miled, Samad Ashrafi, Wolfgang Maier, Frank Surup and Marc Stadler

Nat. Prod. Bioprospect., 2026, 16
DOI: 10.1007/s13659-025-00579-8

Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients

Yuben Qiao, Xiaodong Zhang, Qianqian Xu, Ikuro Abe and Aitao Li

Green Synthesis and Catalysis, 2025
DOI: 10.1016/j.gresc.2025.05.005

Montagnulans A–D with Anti-Osteoclastogenic Activity from the Marine Fungus Montagnula sp. GXIMD 02514

Miaoping Lin, Humu Lu, Jiaxi Wang, Huangxue Qin, Xinya Xu, Chenghai Gao, Yonghong Liu, Yanhui Tan and Xiaowei Luo

Marine Drugs, 2025, 23, 416
DOI: 10.3390/md23110416

Design, synthesis, and mechanism of anti-cancer activity of novel spiro tetramic acids

Shi Xiang, Mengjiao Lv, Chenghao Wang, Zhichao Wang, Hui Chen, Pei Lv and Chao Yang

Bioorganic & Medicinal Chemistry Letters, 2026, 135, 130566
DOI: 10.1016/j.bmcl.2026.130566

Discovery, Herbicidal Activity and Biosynthesis of a Novel Natural Tetramic Acid from Alternaria Species

He Wang, Yanjing Guo, Qing Liu, Jing Zhang, Qianlong Zhang, Mingying Yang, Qizhen Chen, Sheng Qiang, Bernal E. Valverde and Shiguo Chen

Advanced Science, 2025, 12
DOI: 10.1002/advs.202416188

cis-Decalinoyltetramic Acid Derivatives from the Palm Fungus Leptosporella arengae TBRC-BCC32590

Chakapong Intaraudom, Nantiya Bunbamrung, Aibrohim Dramae, Sutichai Nithithanasilp, Nattawut Boonyuen, Chitti Thawai, Khomsan Supong, Patchanee Auncharoen, Pranee Rachtawee and Pattama Pittayakhajonwut

J. Nat. Prod., 2025, 88, 2656
DOI: 10.1021/acs.jnatprod.5c01018

Talarotetramates A–F, Decalin-Containing Tetramic Acids as Ferroptosis Inhibitors from the Deep-Sea-Derived Fungus Talaromyces sp. gb505

Wenjing Tian, Xuan Chen, Gaiyun Zhang, Linfeng Gong, Junxiong Lin, Bihong Hong, Lisheng Li and Siwen Niu

J. Nat. Prod., 2025, 88, 1858
DOI: 10.1021/acs.jnatprod.5c00679

Radical Haloazidation of 1,5-Enenitriles for Making N-Haloimines and Sequential Triazolation to Form Tricyclics

Xiaoming Ma, Mifei Yu, Zijie Gao, Jia-Yin Wang, Hang-Dong Zuo, Sai Zhang, Shenghu Yan, Yue Zhang and Wei Zhang

Org. Lett., 2026
DOI: 10.1021/acs.orglett.6c00773

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining

Bruno Perlatti, Sandeep Vellanki, Yalong Zhang, Yi-Ming Chiang, Yingxia Hu, Mengdi Yuan, Kyle Dunbar, Abigail Fine, Michelle F. Grau, Sheena Li, Timothy O’Donnell, Rajani Shenoy, Hongtao Li, Hui Shi, Xia Xu, Zeyu Chen, Tara Arvedson, Yi Tang, Robert A. Cramer, Victor Cee and Colin J. B. Harvey

ACS Cent. Sci., 2026, 12, 197
DOI: 10.1021/acscentsci.5c02019

Recent advances in chemistry and bioactivity of decalin-containing natural products (2014–2025)

Yaqi Lu, Yuyao Feng, Miaoping Lin, Humu Lu, Xiaodong Jiang, Xinya Xu, Yonghong Liu and Xiaowei Luo

Bioorganic Chemistry, 2026, 171, 109549
DOI: 10.1016/j.bioorg.2026.109549

One new rearranged pyranone derivative with antibacterial activity from Xylaria curta YSJ-5

Shan-Shan Wei, Dao-Jun Rong, Jia-Ying Lai, Chen Chen, Si-Ran Li, Zhong-Hua Yu and Hai-Bo Tan

Phytochemistry Letters, 2025, 70, 104075
DOI: 10.1016/j.phytol.2025.104075

Colletotrichalasin A: a hepatoprotective decalin-tetramic acid derivative featuring a pentacyclic 6/6/5/6/5 ring skeleton from the endophytic fungus Colletotrichum gloeosporioides MT-51 of Huperzia serrata

Bei-Bei Zhang, Hong-Yun Yang, Xiao-Yun Yan, Na Xiong, Lin Zhang, Xiao Liu, Pei-Cheng Zhang, She-Po Shi, Xu Zhang and Juan Wang

Tetrahedron Letters, 2025, 168, 155691
DOI: 10.1016/j.tetlet.2025.155691