Synthesis of new trans-ferulic acid derivatives as potential anticancer agents and VEGFR-2 inhibitors

Asmaa N. Mohie, Mahmoud A. Doheim, Ragab A. El Masry, Ayman M. Gomaa, Rofaida Salem, Haytham O. Tawfik and Wagdy M. Eldehna

RSC Med. Chem., 2026, 17, 1636
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Recent advancements of pyrimidine chemistry thriving deeper into drug discovery

Glanish Jude Martis, Sneha O, Rajkumar Bhat D and Praveen S. Mugali

Synthetic Communications, 2025, 55, 863
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Synthesis of anticancer agents: molecular docking and ADME studies of new hydropyrimidine linked amide-pyridine derivatives

Rajendran Aarthi, Chin-King Looi, Chun-Wai Mai and Chennan Ramalingan

Future Medicinal Chemistry, 2026, 1
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Design, synthesis, antimicrobial evaluation, and molecular modeling of new sulfamethoxazole and trimethoprim analogs as potential DHPS/DHFR inhibitors

Lina M.A. Abdel Ghany, Noha Ryad, Mohamed S. Abdel-Aziz, Hany M. Abd El-Lateef, Islam Zaki and Botros Y. Beshay

Journal of Molecular Structure, 2024, 1309, 138170
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In vitro and in silico evaluation of 4'-hydroxy-[1,1'-biphenyl]-4-carbohydrazide Schiff base and oxadiazole derivatives targeting EGFR allosteric site

Wurood A. Shihab, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Mai F. AlSakhen, Sana I. Kanaan, Khaled M. Saleh and Salem R. Yasin

Chem. Pap., 2024, 78, 7951
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Natural Inhibitors of Salmonella MDR Efflux Pumps AcrAB and AcrD: An Integrated In Silico, Molecular, and In Vitro Investigation

Azza S. El-Demerdash, Shimaa A. Kamel, Eman Y. T. Elariny, Hanan Henidi, Yasmin Mahran, Hadil Alahdal, Abdulrahman M. Saleh and Rehab A. Ibrahim

IJMS, 2024, 25, 12949
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Targeting Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2): Latest Insights on Synthetic Strategies

Carolina S. Marques, Pedro Brandão and Anthony J. Burke

Molecules, 2024, 29, 5341
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Thymoquinone-conjugated liposomes improve cytotoxic and proapoptotic effects against hepatocellular cancer by altering the EGFR/ERK/MEK signaling axis

Shaymaa A. Abdulmalek, Fatma A. Mahmoud, Doaa Awad, Abdulrahman M. Saleh, Ayman I. Elkady, Doaa A. Ghareeb and Mahmoud Balbaa

Discov Onc, 2025, 16
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Multifunctional 1,3,4-oxadiazole-based donor-acceptor fluorophores exhibiting advanced photophysical properties for forensic and security applications and in silico anticancer evaluation.

Mohammed D. Sharahili, Saeed Samman, Jihan Qurban, Amnah S. Al Zbedy, Nahla Albarakati, Ebtesam Al-Mutairi, Amerah Alsoliemy and Nashwa M. El-Metwaly

Journal of Photochemistry and Photobiology A: Chemistry, 2026, 478, 117186
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Heterocyclic anticancer agents targeting VEGFR-2: synthetic approaches to key scaffolds

Shraddha D. Bhor, Kalyani R. Thombre, Krishna R. Gupta and Milind J. Umekar

Chem. Pap., 2026
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Ambient Temperature Metal‐Free Thiomethylation of Chloroheteroarenes and Chloropurines

Manisha A. Patel, Raj K. Vora, Yogesh S. Sanghvi and Anant R. Kapdi

Chemistry An Asian Journal, 2024, 19
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In-Silico profiling of new pyrazoline derivatives as histone deacetylase 2 and 6 inhibitors

Yasir Muhsin, Ameer Alwash and Shayma Hafidh

Turkish Computational and Theoretical Chemistry, 2025, 9, 173
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Design, semi-synthesis, anti-cancer assessment, docking, MD simulation, and DFT studies of novel theobromine-based derivatives as VEGFR-2 inhibitors and apoptosis inducers

Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Aisha A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Mostafa.A. Elhendawy, Murrell Godfrey and Ahmed M. Metwaly

Computational Biology and Chemistry, 2023, 107, 107953
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Discovery of Novel 1,3,5‐trisubstituted‐2‐thioxo‐imidazole Derivatives as Potential Aromatase Inhibitors: Design, Synthesis, In Vitro Anti‐Breast Cancer Screening and Molecular Docking Studies

Mohamed F. Youssef, Jehan A. Hasanen, Alaa A. Shehata, Abdulrahman M. Saleh, Youstina William Rizzk and Azza M. Abdallah

Drug Development Research, 2026, 87
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Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah and Mona S. El-Zoghbi

Pharmaceuticals, 2023, 16, 1303
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Biochemical and molecular evaluation of resveratrol and selenium nanoparticles in managing type 2 diabetes and its complications

Aya Y. Soliman, Nihal M. Elguindy, Abdulrahman M. Saleh and Mahmoud Balbaa

Sci Rep, 2025, 15
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Role of IRE1α/XBP1/CHOP/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo and Molecular Docking Simulation Approaches

Walaa Bayoumie El Gazzar, Heba Bayoumi, Heba S. Youssef, Tayseer A. Ibrahim, Reham M. Abdelfatah, Noha M. Gamil, Mervat K. Iskandar, Amal M. Abdel-Kareim, Shaymaa M. Abdelrahman, Mohammed A. Gebba, Mona Atya Mohamed, Maha M. Mokhtar, Tayseir G. Kharboush, Nervana M. Bayoumy, Hatun A. Alomar and Amina A. Farag

Toxics, 2024, 12, 445
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Insights into Clematis cirrhosa L. Ethanol Extract: Cytotoxic Effects, LC-ESI-QTOF-MS/MS Chemical Profiling, Molecular Docking, and Acute Toxicity Study

Manal I. Alruwad, Riham Salah El Dine, Abdallah M. Gendy, Abdulrahman M. Saleh, Mohamed A. Khalaf, Hala M. El Hefnawy and Manal M. Sabry

Pharmaceuticals, 2024, 17, 1347
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New benzimidazole‐oxadiazole derivatives as potent VEGFR‐2 inhibitors: Synthesis, anticancer evaluation, and docking study

Ulviye Acar Çevik, Ismail Celik, Şennur Görgülü, Zeynep Deniz Şahin Inan, Hayrani Eren Bostancı, Yusuf Özkay and Zafer Asım Kaplacıklı

Drug Development Research, 2024, 85
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Discovery of New Immunomodulatory Anticancer Thalidomide Analogs: Design, Synthesis, Biological Evaluation and In Silico Studies

Abdallah E. Abdallah, Ibrahim H. Eissa, Ahmed B. M. Mehany, Ismail Celik, Helmy Sakr, K. H. Metwaly, Khaled El‐Adl and Mohamed Ayman El‐Zahabi

Chemistry & Biodiversity, 2025, 22
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New immunomodulatory anticancer quinazolinone-based thalidomide analogs: design, synthesis and biological evaluation

Maged Mohammed Saleh Al Ward, Abdallah E Abdallah, Mohamed F Zayed, Rezk R Ayyad, Tamer M Abdelghany, Dina Abed Bakhotmah and Mohamed Ayman El-Zahabi

Future Medicinal Chemistry, 2024, 16, 2523
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Design, synthesis, anticancer evaluation, biological screening, and computational study of novel 6,7-dimethoxyquinazoline derivatives as VEGFR-2 inhibitors and apoptotic inducers

Mostafa M.A. Aref, Abdallah E. Abdallah, Mohammed A. Dahab, Abeer A. Mohamed, Ismail Celik, Wafa A. Bawazir, Ahd A. Mansoure, Aisha Taib Alnami, Mennatullah N. Abdelhamed and Mohamed Ayman El-Zahabi

European Journal of Medicinal Chemistry, 2026, 301, 118187
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Detection of Mycobacteria in Arabian camels and antimycobacterial potential of Moringa oleifera

Sahar A. Allam, Eman Mahrous, Sahar T. M. Tolba, Samy M. Mohamed, Mohamed T. Ragab and Rania I. Mohamed

Sci Rep, 2025, 15
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Synthesis, antiproliferative evaluation and in silico studies of new quinazoline derivatives as VEGFR-2 inhibitors

Abdelsalam Mohamed Abdelsalam Ouf, Adel A. Marzouk, Montaser Sh. A. Shaykoon, Ismail Celik, Dina A. Bakhotmah, Ahd A. Mansour, Mariam K. Alamoudi, Abdallah M. Alfayomy and Mohamed Ayman El-Zahabi

Future Medicinal Chemistry, 2025, 17, 1407
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Design and synthesis of thiadiazoles as anticancer, apoptotic, and VEGFR-2 inhibitors

Walid E. Elgammal, Hazem Elkady, Mohammed A. Dahab, Hazem A. Mahdy, Mohamed Hagras, Ahmed Nofal, Bshra A. Alsfouk, Eslam B. Elkaeed, Ibrahim H. Eissa and Ahmed M. Metwaly

Future Medicinal Chemistry, 2025, 17, 915
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In silico and in vitro evaluation of novel carbothioamide-based and heterocyclic derivatives of 4-(tert-butyl)-3-methoxybenzoic acid as EGFR tyrosine kinase allosteric site inhibitors

Imad M. Al-Rubaye, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Mai F. AlSakhen, Sana I. Kanaan, Khaled M. Saleh and Salem R. Yasin

Results in Chemistry, 2024, 7, 101329
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Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets

Alia Mushtaq, Peng Wu and Muhammad Moazzam Naseer

Pharmacology & Therapeutics, 2024, 254, 108579
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Molecular modelling and antimicrobial activity of newly synthesized benzothiazolo[3,2-a]pyrimidine clubbed thiazole derivatives

Arwa Alharbi, Adel I. Alalawy, Shaker T. Alsharif, Alaa M. Alqahtani, Ali H. Alessa, Mansoor Alsahag, Ali Alisaac and Nashwa M. El-Metwaly

Heliyon, 2024, 10, e38905
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Anticancer activity of hydrazones in the last quinquennial period: A special emphasis on various enzyme targets and SAR

Shyama Charan, Naazneen Maksud, Amisha Gupta, Sonia Devi, M. Mumtaz Alam, Mymoona Akhter, Sharba Tasneem, Darakhshan Parveen, Ahasan and M. Shaquiquzzaman

European Journal of Medicinal Chemistry, 2026, 302, 118305
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Inhibition of malate dehydrogenase via nanoselenium coupling with nanocellulose composite in MCF-7 breast carcinoma cells

Mostafa M. El-Sheekh, El-Refaie Kenawy, Wesam E. Yousuf and Tarek M. Mohamed

Cancer Nano, 2024, 15
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Development and Validation of QBD-Assisted Using Central Composite Design RP-HPLC Method for Lobeglitazone Sulfate and Glimipiride in Bulk and Its Combined Dosage Form

A. Marina Juliet and Punniyakoti Veeraveedu Thanikachalam

Chromatographia, 2025, 88, 381
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