Microneedle patches: a new vantage point for diabetic wound treatments

Ashkan Bigham, Atefeh Zarepour, Arezoo Khosravi, Siavash Iravani and Ali Zarrabi

Biomater. Sci., 2025, 13, 379
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Recent advances of hydrogels as smart dressings for diabetic wounds

Xu Wang, Yuhan Yang, Weifeng Zhao, Zhou Zhu and Xibo Pei

J. Mater. Chem. B, 2024, 12, 1126
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Temperature-responsive fluorescent polygalacturonic acid: a step towards wound monitoring with smartphone imaging

Dana Kaafarani, Jad Kaj and Pierre Karam

Mater. Adv., 2025, 6, 3841
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Recent developments and future perspectives of microfluidics and smart technologies in wearable devices

Sasikala Apoorva, Nam-Trung Nguyen and Kamalalayam Rajan Sreejith

Lab Chip, 2024, 24, 1833
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Microneedle-assisted percutaneous delivery of methotrexate-loaded nanoparticles enabling sustained anti-inflammatory effects in psoriasis therapy

Hongyao Du, Jing Yang, Mo Li, Yuting Xia, Yan Li, Jintao Zhu, Lianbin Zhang and Juan Tao

J. Mater. Chem. B, 2024, 12, 2618
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Advances in microneedle technology for skin wound healing: integrating nanomaterials and intelligent drug delivery systems

Yuqing Wang, Yao He, Tao Zhang and Yunfeng Lin

Nanoscale, 2025, 17, 18505
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Transdermal drug delivery using a porous microneedle device driven by a hydrogel electroosmotic pump

Gaobo Wang, Kosuke Kato, Izuru Aoki, Sae Ichinose, Daisuke Inoue, Soichiro Tottori and Matsuhiko Nishizawa

J. Mater. Chem. B, 2024, 12, 1490
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Microneedle-mediated drug delivery for scar prevention and treatment

Bricard Mbituyimana, Clemence Futila Bukatuka, Fuyu Qi, Guangrui Ma, Zhijun Shi and Guang Yang

Drug Discovery Today, 2023, 28, 103801
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How biomimetic nanofibers advance the realm of cutaneous wound management: The state-of-the-art and future prospects

Niloofar Eslahi, Foad Soleimani, Roya Lotfi, Fatemeh Mohandes, Abdolreza Simchi and Mehdi Razavi

Progress in Materials Science, 2024, 145, 101293
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Revolutionizing Transdermal Patches: Navigating Clinical Challenges and Technological Progress

Shubham Malik, Chandan Sharma, Nishant Thakur, Bhupinder Kaur and Neeraj Bainsal

CDTH, 2026, 21, 6
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Retrospective study to assess the efficiency of a novel wound healing patch – Zioheal

Krishna Sree Adluri, G. Sharath Chandra Reddy, Bala Ganesh Vedati and Rajeshwara Krishna Prasad Adluri

Medicover Journal of Medicine, 2025, 2, 9
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Intelligent responsive natural macromolecular hydrogel: a new paradigm to lead diabetic wound healing

Yuqing Shi and Yumeng Xue

Journal of Drug Delivery Science and Technology, 2026, 120, 108133
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Nanomaterials-incorporated polymeric microneedles for wound healing applications

Wei Duan, Keying Xu, Sheng Huang, Yue Gao, Yong Guo, Qiying Shen, Qiaolin Wei, Wei Zheng, Quan Hu and Jia-Wei Shen

International Journal of Pharmaceutics, 2024, 659, 124247
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Dynamic hydrogel-integrated microneedle patch with extracellular vesicles encapsulation for wound healing

Dan Wu, Xiangyi Wu, Qichen Luan, Qing Tang, Lu Fan, Xin Shou, Xia Gao, Xiaoyun Qian and Yuanjin Zhao

Chemical Engineering Journal, 2024, 493, 152252
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Polymer‐ and Lipid‐Based Nanostructures Serving Wound Healing Applications: A Review

Fatma N. Cetin, Arn Mignon, Sandra Van Vlierberghe and Kristyna Kolouchova

Adv Healthcare Materials, 2025, 14
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Recent Progress in Flexible Medical Sensors: Materials, Mechanisms, and Multifunctional Applications

Yingqing Yu, Qiushi Wang, Jiandong Cui, Yazhou Yuan, Hao Zhang, Haibo Liu, Yunhong Liang and Suqian Ma

Anal. Chem., 2025, 97, 27478
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Emerging biomedical technologies for scarless wound healing

Xinyue Cao, Xiangyi Wu, Yuanyuan Zhang, Xiaoyun Qian, Weijian Sun and Yuanjin Zhao

Bioactive Materials, 2024, 42, 449
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Engineering the Functional Expansion of Microneedles

Shengfei Yang, Yihua Xu, Mingjian Zhu, Yawei Yu, Weitong Hu, Tianyuan Zhang and Jianqing Gao

Advanced Materials, 2025, 37
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Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective

Devesh Kumar, Shubham Pandey, Jailani Shiekmydeen, Mohit Kumar, Shruti Chopra and Amit Bhatia

AAPS PharmSciTech, 2025, 26
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Copper-gallate metal-organic framework encapsulated multifunctional konjac glucomannan microneedles patches for promoting wound healing

Qida Zong, Xinxuan Peng, Huiying Wu, Yan Ding, Xuanjiayi Ye, Xiuwei Gao, Wei Sun and Yinglei Zhai

International Journal of Biological Macromolecules, 2024, 257, 128581
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Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing

Tae-Hee Kim, Min-Sung Kim, Nam-Gyun Kim, Nguyen Vu Linh, Hien Van Doan, Young-Mog Kim, Sang-Hyug Park and Won-Kyo Jung

Tissue Eng Regen Med, 2024, 21, 1007
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Pharmaceutical applications of chitosan in skin regeneration: A review

Jie Wang, Xunxin Duan, Donghuo Zhong, Mengqi Zhang, Jianying Li, Zhijian Hu and Feng Han

International Journal of Biological Macromolecules, 2024, 261, 129064
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Localized Delivery of Bioactives using Structured Liposomal Gels

Deepak Kumar, Kamal Dua and Sanjay Tiwari

CPD, 2023, 29, 3206
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Microneedles in diabetic wound care: multifunctional solutions for enhanced healing

Xichao Jian, Yaping Deng, Shune Xiao, Fang Qi and Chengliang Deng

Burns & Trauma, 2025, 13
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Advances of transdermal drug delivery system based on extracellular vesicles

Haoqiang Qin, Min Zhang, Hao Wang, Mingyue Peng, Zhenjing Liu, Shaoqian Wang, Ziyang Wang and Kehai Liu

Journal of Drug Delivery Science and Technology, 2025, 105, 106647
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Antibacterial, injectable, and adhesive hydrogel promotes skin healing

Zilong Fang, Tao Lin, Shuai Fan, Xing Qiu, Ziqing Zhong, Ganghua Yang, Jianqiu Yang, Guoqing Zhang, Yang Feng, Fanrong Ai, Qingming Shi and Wenbing Wan

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1180073

Emerging electroactive bio-microneedles for innovative minimally invasive theranostic applications

Ying Liu, Xiaomin Luo, Lijuan Chen, Zhilong Qiao, Liuying Li, Chengcheng Si and Xinhua Liu

Int. J. Extrem. Manuf., 2026, 8, 032001
DOI: 10.1088/2631-7990/ae3218

Recent Advances in Microneedle Technology for Skin Antiaging

Bin Liu, Liping Zhao, Ziyu Wang, Chuanzhi Zhu, Huailong Chang and Hongqian Chu

ACS Appl. Bio Mater., 2025, 8, 7567
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Albumin-Based Microneedles for Spatiotemporal Delivery of Temozolomide and Niclosamide to Resistant Glioblastoma

Zhipeng Yang, Haoyuan Li, Biao Yang and Yanjie Liu

ACS Appl. Mater. Interfaces, 2024, 16, 44518
DOI: 10.1021/acsami.4c09394

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery

Satish Rojekar, Swapnali Parit, Amol D. Gholap, Ajit Manchare, Sopan N. Nangare, Navnath Hatvate, Vrashabh V. Sugandhi, Keshav Raj Paudel and Rahul G. Ingle

Pharmaceutics, 2024, 16, 1398
DOI: 10.3390/pharmaceutics16111398

Rational Design and Adaptive Transdermal Cargo Delivery of Microneedle in Dermatologic Therapeutics

Yan Shi, Jiaxuan Zhao, Jinrui Li, Ziye Lin, Lu Liu and Ming Kong

Small, 2025, 21
DOI: 10.1002/smll.202506886

Microneedle dressing incorporating deferoxamine-loaded silk fibroin nanoparticles for diabetic wound therapy

Elaf Mahmood Shihab, Saja Majeed Shareef, Zinah Essam Hameed, Yasir Qasim Almajidi, Marwa M. Kamil, Mastafa H. Al-Musawi, Fariborz Sharifianjazi, Ketevan Tavamaishvili, Fatemeh Mortazavi Moghadam, Salar Nasr Esfahani, Mohamadreza Tavakoli and Marjan Mirhaj

International Journal of Pharmaceutics, 2026, 696, 126746
DOI: 10.1016/j.ijpharm.2026.126746

Current trend on preparation, properties, and wound healing applications of polysaccharide-based hydrogel patches: A review

Jiaqi Tan, Rong Dong, Ruoshi Zhang, Xiaojun Liao and Hongkun Xue

Carbohydrate Polymers, 2026, 377, 124869
DOI: 10.1016/j.carbpol.2025.124869

Hemostatic Biopolymers: A Natural Approach for Revolutionizing Blood Loss Control

Supriya Shidhaye, Priyanka Singanwad, Mayuri Gajghate, Neha Raut, Ruchi Khobragade, Milind Umekar and Rashmi Trivedi

Polymer-Plastics Technology and Materials, 2025, 64, 1315
DOI: 10.1080/25740881.2025.2461626

A closed-loop smart dressing based on microneedle and electrochemical micropump for early diagnosis and in-time therapy of chronic wound

Huiting Zhao, Guomin Liang, Jiyuan Xiong, Xu Wang, Xiaoming Hu and Zewen Wei

Sensors and Actuators B: Chemical, 2024, 417, 136092
DOI: 10.1016/j.snb.2024.136092

Self‐Adaptive Wound Dressings for Wound Healing and Repair

Xin Zhao, Huiru Xu, Yuchen Sun, Yutong Yang and Baolin Guo

Advanced Materials, 2025
DOI: 10.1002/adma.202515854

Photothermal-controlled microneedle for transdermal delivery of metal-phenolic nanozyme with staged multifunctions to accelerate healing of infected diabetic wounds

Dong Yan, Guoqi Cao, Yikai Gao, Yiping Wang, Wenqiang Zhang, Kun Wang, Shumei Mao, Chengde Li, Guangdong Zhou, Huitang Xia, Wufei Dai, Xiaoyu Yan and Yibing Wang

Materials Today Bio, 2025, 31, 101554
DOI: 10.1016/j.mtbio.2025.101554

Global trends in clinical trials involving engineered biomaterials

Mahim Lele, Shaunak Kapur, Sarah Hargett, Nivedhitha Malli Sureshbabu and Akhilesh K. Gaharwar

Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.abq0997

It Takes Two to Tangle: Microneedle Patches Co‐delivering Monoclonal Antibodies and Engineered Antimicrobial Peptides Effectively Eradicate Wound Biofilms

Yajuan Su, Shatil S. M. Shahriar, Syed Muntazir Andrabi, Chenlong Wang, Navatha Shree Sharma, Yizhu Xiao, Shannon L. Wong, Guangshun Wang and Jingwei Xie

Macromolecular Bioscience, 2024, 24
DOI: 10.1002/mabi.202300519

Endogenous/exogenous stimuli‐responsive smart hydrogels for diabetic wound healing

Saadullah Khattak, Ihsan Ullah, Mohammad Sohail, Muhammad Usman Akbar, Mohd Ahmar Rauf, Salim Ullah, Jianliang Shen and Hong‐Tao Xu

Aggregate, 2025, 6
DOI: 10.1002/agt2.688

Application of ultrasound and ultrasound-responsive materials in wounds: A systematic review

Jialei Luo, Liwan Song, Xinyi Yan, Xiaolu Ma, Jianqing Gao, Ying Luo and Gaoyi Yang

International Journal of Pharmaceutics: X, 2026, 11, 100485
DOI: 10.1016/j.ijpx.2026.100485

Ultrasmall Self-Cascade Bimetallic Au2Pd3 Nanozymes Encapsulated Hydrogel Microneedles for Photothermal-Augmented Nanocatalytic Therapy of Diabetic Wound Infections

Weiwei Chen, Fan Yang, Xi Chen, Cheng Jin, Ninghong Yin, Mengya Sun, Yinbang Zheng, Ke Yang, Zefeng Wang, Dinggeng He, Li Wang and Luo Hai

ACS Appl. Mater. Interfaces, 2025, 17, 53295
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Microneedle-integrated biosensors for smart wound monitoring

Raquel L. Pereira, Xavier Muñoz-Berbel and Sanna Sillankorva

Biosensors and Bioelectronics, 2026, 302, 118547
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Progressive microneedles for targeting and intelligent drug delivery

Jiaqi Li, Qing Xia, Shuwen Ma, Zhi Wang, Teng Guo, Nianping Feng and Yongtai Zhang

Asian Journal of Pharmaceutical Sciences, 2025, 20, 101051
DOI: 10.1016/j.ajps.2025.101051

Emerging approaches in keloid scar healing: The synergistic role of nanoparticles and phytochemicals

Devadass Jessy Mercy, Koyeli Girigoswami and Agnishwar Girigoswami

Chemical Engineering Journal, 2025, 522, 168048
DOI: 10.1016/j.cej.2025.168048

Advances of Microneedle Patch in Diabetic Wound Healing

Yong-Nian Zeng, Yin-Li Jin and Wei Li

Pharmaceutical Fronts, 2024, 06, e20
DOI: 10.1055/s-0043-1777440

Current status and future developments in preparation and application of self-healing hydrogels for biomedical engineering

Yayun Zhu, Hailin Cong and Bing Yu

European Polymer Journal, 2025, 234, 114025
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Wound healing management using microneedle array patch: Journey so far and road ahead

Sriya Panda, Siddhi Pashankar, Saniya Rajput, Rachana Ghewari, Akhilesh Vardikar, Kaustubh Ajit Kolekar, Sachin Kumar Singh, Shweta Inamdar, Kalyani Duparte, S. Hari Rajan and Amarjitsing Rajput

Journal of Drug Delivery Science and Technology, 2025, 114, 107522
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Progress of proteolysis-targeting chimeras (PROTACs) delivery system in tumor treatment

Lianlian Fan, Weifang Tong, Anhui Wei and Xupeng Mu

International Journal of Biological Macromolecules, 2024, 275, 133680
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The Synergistic Potential of Hydrogel Microneedles and Nanomaterials: Breaking Barriers in Transdermal Therapy

Atefeh Golshirazi, Mahsa Mohammadzadeh and Sheyda Labbaf

Macromolecular Bioscience, 2025, 25
DOI: 10.1002/mabi.202400228

Smart patches for healthcare industry: a review of emerging technologies, challenges, and developmental opportunities

K Umapathi, L Priya and Hady Habib Fayek

BioMed Eng OnLine, 2026, 25
DOI: 10.1186/s12938-025-01485-3

Graphene-Based Wound Dressings for Wound Healing: Mechanism, Technical Analysis, and Application Status

Shanguo Zhang, Tianyi Jiang, Ming Li, Haoxiu Sun, Hao Wu, Wenlong Wu, Yu Li and Hongyuan Jiang

ACS Biomater. Sci. Eng., 2024, 10, 6790
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Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals

B.H. Jaswanth Gowda, Mohammed Gulzar Ahmed, Raghu Raj Singh Thakur, Ryan F. Donnelly and Lalitkumar K. Vora

Mol. Pharmaceutics, 2024, 21, 6007
DOI: 10.1021/acs.molpharmaceut.4c00894

Cell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies (Review)

Jielin Song, Tong Zhao, Chuanfu Wang, Xu Sun, Junchao Sun and Zhaohui Zhang

Int J Mol Med, 2025, 56, 1
DOI: 10.3892/ijmm.2025.5567