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Biochemistry, 2025, 64, 266
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A Substantial Structural Conversion of the Native Monomer Leads to in‐Register Parallel Amyloid Fibril Formation in Light‐Chain Amyloidosis

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Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains

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iAMY-SCM: Improved prediction and analysis of amyloid proteins using a scoring card method with propensity scores of dipeptides

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Mechanisms of Organ Damage and Novel Treatment Targets in AL Amyloidosis

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Hemato, 2022, 3, 47
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Understanding and Overcoming Biochemical Diversity in AL Amyloidosis

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Conformational Differences in the Light Chain Constant Domain of Immunoglobulin G and Free Light Chain May Influence Proteolysis in AL Amyloidosis

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Journal of Molecular Biology, 2024, 436, 168837
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Structural and immunogenomic insights into B-cell receptor activation

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Evaluation of in silico tools for the prediction of protein and peptide aggregation on diverse datasets

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Truncation of the constant domain drives amyloid formation by immunoglobulin light chains

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Understanding Mesangial Pathobiology in AL-Amyloidosis and Monoclonal Ig Light Chain Deposition Disease

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Kidney International Reports, 2020, 5, 1870
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Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains

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Journal of Molecular Biology, 2020, 432, 845
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Outcome of patients with severe AL amyloidosis and biopsy-proven renal involvement ineligible for bone marrow transplantation

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Cryo-EM reveals structural breaks in a patient-derived amyloid fibril from systemic AL amyloidosis

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Nat Commun, 2021, 12
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Towards a novel target therapy for renal diseases related to plasma cell dyscrasias: The example of AL amyloidosis

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In Silico Modeling of the Influence of Environment on Amyloid Folding Using FOD-M Model

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IJMS, 2021, 22, 10587
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Design and Characterization of Model Systems that Promote and Disrupt Transparency of Vertebrate Crystallins In Vitro

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Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis

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Biophysical Chemistry, 2022, 280, 106699
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A conformational fingerprint for amyloidogenic light chains

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The Critical Role of the Variable Domain in Driving Proteotoxicity and Aggregation in Full-length Light Chains

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The Cryo-EM Structure of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis

Sarita Puri, Tim Schulte, Antonio Chaves-Sanjuan, Giulia Mazzini, Serena Caminito, Carlo Pappone, Luigi Anastasia, Paolo Milani, Giampaolo Merlini, Martino Bolognesi, Mario Nuvolone, Giovanni Palladini and Stefano Ricagno

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A Conservative Point Mutation in a Dynamic Antigen-binding Loop of Human Immunoglobulin λ6 Light Chain Promotes Pathologic Amyloid Formation

Daniele Peterle, Elena S. Klimtchuk, Thomas E. Wales, Florian Georgescauld, Lawreen H. Connors, John R. Engen and Olga Gursky

Journal of Molecular Biology, 2021, 433, 167310
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Cu(II) binding to the λ6aJL2-R24G antibody light chain protein associated with light chain amyloidosis disease: The role of histidines

Angel E. Pelaez-Aguilar, Fernanda Mata-Salgado, Alan Morales-Ortiz, César Millán-Pacheco, Clarita Olvera-Carranza, Jesus Salgado-Delgado, Nina Pastor and Lina Rivillas-Acevedo

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Learning from Patients: The Interplay between Clinical and Laboratory Research in AL Amyloidosis

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Hemato, 2021, 3, 3
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Big versus small: The impact of aggregate size in disease

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Protein Science, 2023, 32
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Antibody Aggregation: A Problem Within the Biopharmaceutical Industry and Its Role in AL Amyloidosis Disease

Kate Sheehan, Hyesoo Jeon, Sinéad C. Corr, Jerrard M. Hayes and K. H. Mok

Protein J, 2025, 44, 1
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The molecular landscape of AL amyloidosis

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Br J Haematol, 2025, 206, 1297
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The AL Amyloid Fibril: Looking for a Link between Fibril Formation and Structure

Christian Haupt

Hemato, 2021, 2, 505
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Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain AL amyloidosis patient

Paolo Swuec, Francesca Lavatelli, Masayoshi Tasaki, Cristina Paissoni, Paola Rognoni, Martina Maritan, Francesca Brambilla, Paolo Milani, Pierluigi Mauri, Carlo Camilloni, Giovanni Palladini, Giampaolo Merlini, Stefano Ricagno and Martino Bolognesi

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Depth of response prior to autologous stem cell transplantation predicts survival in light chain amyloidosis

Iuliana Vaxman, M. Hasib Sidiqi, Abdullah S. Al Saleh, Shaji Kumar, Eli Muchtar, Angela Dispenzieri, Francis Buadi, David Dingli, Martha Lacy, Suzanne Hayman, Nelson Leung, Wilson Gonsalves, Taxiarchis Kourelis, Rahma Warsame, William Hogan and Morie Gertz

Bone Marrow Transplant, 2021, 56, 928
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Complete variable domain sequences of monoclonal antibody light chains identified from untargeted RNA sequencing data

Allison Nau, Yun Shen, Vaishali Sanchorawala, Tatiana Prokaeva and Gareth J. Morgan

Front. Immunol., 2023, 14
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Site-Specific Interactions with Copper Promote Amyloid Fibril Formation for λ6aJL2-R24G

Angel E. Pelaez-Aguilar, Gilberto Valdés-García, Leidys French-Pacheco, Nina Pastor, Carlos Amero and Lina Rivillas-Acevedo

ACS Omega, 2020, 5, 7085
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Unfolding and Aggregation Pathways of Variable Domains from Immunoglobulin Light Chains

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Biochemistry, 2023, 62, 1000
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AB-Amy: machine learning aided amyloidogenic risk prediction of therapeutic antibody light chains

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Antibody Therapeutics, 2023, 6, 147
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Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion

Bibiana Rius, Jaleh S. Mesgarzadeh, Isabelle C. Romine, Ryan J. Paxman, Jeffery W. Kelly and R. Luke Wiseman

Blood Advances, 2021, 5, 1037
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Monoclonal Gammopathies of Renal Significance: Renal Biopsy and Beyond

Paolo Menè, Lorenzo De Alexandris, Alessandra Moioli, Salvatore Raffa and Antonella Stoppacciaro

Cancers, 2020, 12, 1741
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Protein Misfolding during Pregnancy: New Approaches to Preeclampsia Diagnostics

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IJMS, 2019, 20, 6183
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Validation of a renal staging system and its association with renal amyloid deposition burden in AL amyloidosis

Ying Yao, Shuang Wang, Dan-Yang Li, Xiao-Juan Yu, Jia-Yi Liu, Zhi-Xiang Qiu, Fu-De Zhou and Su-Xia Wang

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Computational evidences of a misfolding event in an aggregation‐prone light chain preceding the formation of the non‐native pathogenic dimer

Fausta Desantis, Mattia Miotto, Edoardo Milanetti, Giancarlo Ruocco and Lorenzo Di Rienzo

Proteins, 2024, 92, 797
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Current Understanding of Systemic Amyloidosis and Underlying Disease Mechanisms

Maria M. Picken

The American Journal of Cardiology, 2022, 185, S2
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Diagnostic Challenges and Solutions in Systemic Amyloidosis

Rivka Goldis, Batia Kaplan, Olga (Lesya) Kukuy, Michael Arad, Hila Magen, Efrat Shavit-Stein, Amir Dori and Avi Livneh

IJMS, 2023, 24, 4655
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Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody

Jing Zhen, Jennifer Lee, Yueyang Wang, Lena McLaughlin, Fei Yang, Zhengjian Li and Jihong Wang

Antibodies, 2023, 12, 59
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Structural, Biophysical, and Computational Studies of a Murine Light Chain Dimer

Ricardo H. Arriaza, A. Brenda Kapingidza, Coleman Dolamore, Kriti Khatri, Andrea O’Malley, Jill Glesner, Sabina Wuenschmann, Noah P. Hyduke, William Easley, Charline Chhiv, Anna Pomés and Maksymilian Chruszcz

Molecules, 2024, 29, 2885
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Multiple Myeloma–Associated Ig Light Chain Crystalline Cast Nephropathy

Hirotoshi Matsumura, Yusuke Furukawa, Takashi Nakagaki, Chikako Furutani, Sayaka Osanai, Keiichi Noguchi, Masafumi Odaka, Masafumi Yohda, Hiroshi Ohtani, Yoshihiro Michishita, Yoshinari Kawabata, Atsushi Kitabayashi, Sho Ikeda, Mizuho Nara, Atsushi Komatsuda, Naoto Takahashi and Hideki Wakui

Kidney International Reports, 2020, 5, 1595
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Current status and prospect of anti-amyloid fibril therapy in AL amyloidosis

Jinghua Wang, Jian Li and Liye Zhong

Blood Reviews, 2024, 66, 101207
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Alpha-B-Crystallin Effect on Mature Amyloid Fibrils: Different Degradation Mechanisms and Changes in Cytotoxicity

Olga V. Stepanenko, M. I. Sulatsky, E. V. Mikhailova, Olesya V. Stepanenko, O. I. Povarova, I. M. Kuznetsova, K. K. Turoverov and A. I. Sulatskaya

IJMS, 2020, 21, 7659
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Investigating Local Sequence‐Structural Attributes of Amyloidogenic Light Chain Variable Domains

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Proteins, 2025, 93, 1451
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Dissecting the Molecular Features of Systemic Light Chain (AL) Amyloidosis: Contributions from Proteomics

Paola Rognoni, Giulia Mazzini, Serena Caminito, Giovanni Palladini and Francesca Lavatelli

Medicina, 2021, 57, 916
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Engineering Stability, Viscosity, and Immunogenicity of Antibodies by Computational Design

Daisuke Kuroda and Kouhei Tsumoto

Journal of Pharmaceutical Sciences, 2020, 109, 1631
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Methods to study the structure of misfolded protein states in systemic amyloidosis

Marcus Fändrich and Matthias Schmidt

Biochemical Society Transactions, 2021, 49, 977
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Understanding AL amyloidosis with a little help from in vivo models

Gemma Martinez-Rivas, Sébastien Bender and Christophe Sirac

Front. Immunol., 2022, 13
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Primary localized gastric amyloidosis: A scoping review of the literature from clinical presentations to prognosis

Xin-Yu Lin, Dan Pan, Li-Xuan Sang and Bing Chang

WJG, 2021, 27, 1132
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Using the Method of Molecular Modeling and Docking to Estimate the Potential Danger of Side Effects of Therapeutic Agents Used with Cardiac Amyloidosis

M. G. Petukhov, N. V. Borushko, A. V. Kayava and M. V. Uspenskaya

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A Novel IGLC2 Gene Linked With Prognosis of Triple-Negative Breast Cancer

Yu-Tien Chang, Wen-Chiuan Tsai, Wei-Zhi Lin, Chia-Chao Wu, Jyh-Cherng Yu, Vincent S. Tseng, Guo-Shiou Liao, Je-Ming Hu, Huan-Ming Hsu, Yu-Jia Chang, Meng-Chiung Lin, Chi-Ming Chu and Chien-Yi Yang

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Proteomics of Multiple Sclerosis: Inherent Issues in Defining the Pathoetiology and Identifying (Early) Biomarkers

Monokesh K. Sen, Mohammed S. M. Almuslehi, Peter J. Shortland, David A. Mahns and Jens R. Coorssen

IJMS, 2021, 22, 7377
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Molecular mechanism of amyloidogenic mutations in hypervariable regions of antibody light chains

Georg J. Rottenaicher, Benedikt Weber, Florian Rührnößl, Pamina Kazman, Ramona M. Absmeier, Manuel Hitzenberger, Martin Zacharias and Johannes Buchner

Journal of Biological Chemistry, 2021, 296, 100334
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Different Dynamics in 6aJL2 Proteins Associated with AL Amyloidosis, a Conformational Disease

Roberto Maya-Martinez, Leidys French-Pacheco, Gilberto Valdés-García, Nina Pastor and Carlos Amero

IJMS, 2019, 20, 4078
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Epidemiology of Amyloidosis and Genetic Pathways to Diagnosis and Typing

Kari Hemminki and Asta Försti

Hemato, 2021, 2, 429
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Antibodies gone bad – the molecular mechanism of light chain amyloidosis

Ramona M. Absmeier, Georg J. Rottenaicher, Hristo L. Svilenov, Pamina Kazman and Johannes Buchner

The FEBS Journal, 2023, 290, 1398
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Histological and proteomic characterization of musculoskeletal amyloidomas

Raffaele Gaeta, Francesco Greco, Federica Anastasi, Lorenzo Andreani, Rodolfo Capanna, Liam A. McDonnell and Alessandro Franchi

Pathologica, 2025, 117, 278
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CD38 and Anti-CD38 Monoclonal Antibodies in AL Amyloidosis: Targeting Plasma Cells and beyond

Dario Roccatello, Roberta Fenoglio, Savino Sciascia, Carla Naretto, Daniela Rossi, Michela Ferro, Antonella Barreca, Fabio Malavasi and Simone Baldovino

IJMS, 2020, 21, 4129
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On the Structural Diversity and Individuality of Polymorphic Amyloid Protein Assemblies

Liisa Lutter, Liam D. Aubrey and Wei-Feng Xue

Journal of Molecular Biology, 2021, 433, 167124
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Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt and Marcus Fändrich

Nat Commun, 2019, 10
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An updated AL-base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis

Gareth J. Morgan, Allison N. Nau, Sherry Wong, Brian H. Spencer, Yun Shen, Axin Hua, Matthew J. Bullard, Vaishali Sanchorawala and Tatiana Prokaeva

Amyloid, 2025, 32, 129
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Native State Stabilization of Amyloidogenic Proteins by Kinetic Stabilizers: Inhibition of Protein Aggregation and Clinical Relevance

Priyanka, Bitta Raymandal and Santanu Mondal

ChemMedChem, 2024, 19
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Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains

Oren L. Lederberg, Nicholas L. Yan, Julian Sanchez, Wen Ren, Carl Ash, Steven J. Wilkens, Huang Qiu, Bo Qin, Virginia H. Grant, Alex B. Jackman, Robyn L. Stanfield, Ian A. Wilson, H. Michael Petrassi, Derek Rhoades and Jeffery W. Kelly

J. Med. Chem., 2024, 67, 21070
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Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis

Daisuke Takahashi, Eri Matsunaga, Tomohiro Yamashita, Jose M.M. Caaveiro, Yoshito Abe and Tadashi Ueda

Biochemical and Biophysical Research Communications, 2022, 596, 22
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The mechanism of action, pharmacological characteristics, and clinical utility of the amyloid depleter birtamimab for the potential treatment of AL amyloidosis

Giovanni Palladini, Michaela Liedtke, Wagner Zago, Phil Dolan, Gene G. Kinney and Morie A. Gertz

Leukemia & Lymphoma, 2024, 65, 1068
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Protease resistance of ex vivo amyloid fibrils implies the proteolytic selection of disease-associated fibril morphologies

Jonathan Schönfelder, Peter Benedikt Pfeiffer, Tejaswini Pradhan, Johan Bijzet, Bouke P. C. Hazenberg, Stefan O. Schönland, Ute Hegenbart, Bernd Reif, Christian Haupt and Marcus Fändrich

Amyloid, 2021, 28, 243
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An N-glycosylation hotspot in immunoglobulin κ light chains is associated with AL amyloidosis

Alice Nevone, Maria Girelli, Silvia Mangiacavalli, Bruno Paiva, Paolo Milani, Pasquale Cascino, Maggie Piscitelli, Valentina Speranzini, Claudio Salvatore Cartia, Pietro Benvenuti, Ibai Goicoechea, Francesca Fazio, Marco Basset, Andrea Foli, Martina Nanci, Giulia Mazzini, Serena Caminito, Melania Antonietta Sesta, Simona Casarini, Paola Rognoni, Francesca Lavatelli, Maria Teresa Petrucci, Pier Paolo Olimpieri, Stefano Ricagno, Luca Arcaini, Giampaolo Merlini, Giovanni Palladini and Mario Nuvolone

Leukemia, 2022, 36, 2076
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Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM

Lynn Radamaker, Sara Karimi-Farsijani, Giada Andreotti, Julian Baur, Matthias Neumann, Sarah Schreiner, Natalie Berghaus, Raoul Motika, Christian Haupt, Paul Walther, Volker Schmidt, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Sebastian Wiese, Clarissa Read, Matthias Schmidt and Marcus Fändrich

Nat Commun, 2021, 12
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Search for AL amyloidosis risk factors using Mendelian randomization

Charlie N. Saunders, Subhayan Chattopadhyay, Stefanie Huhn, Niels Weinhold, Per Hoffmann, Markus M. Nöthen, Karl-Heinz Jöckel, Börge Schmidt, Stefano Landi, Hartmut Goldschmidt, Paolo Milani, Giampaolo Merlini, Dorota Rowcieno, Philip Hawkins, Ute Hegenbart, Giovanni Palladini, Ashutosh Wechalekar, Stefan O. Schönland, Asta Försti, Richard Houlston and Kari Hemminki

Blood Advances, 2021, 5, 2725
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