A digital microfluidic approach to increasing sample volume and reducing bead numbers in single molecule array assays

Alinaghi Salari, Jose Gilberto Camacho Valenzuela, Nguyen Le, Joshua Dahmer, Alexandros A. Sklavounos, Cheuk W. Kan, Ryan Manning, David C. Duffy, Nira R. Pollock and Aaron R. Wheeler

Lab Chip, 2025, 25, 1669
DOI: 10.1039/D4LC01002G

Thin-film-transistor digital microfluidics for high value in vitro diagnostics at the point of need

Sally Anderson, Ben Hadwen and Chris Brown

Lab Chip, 2021, 21, 962
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Intelligent optoelectrowetting digital microfluidic system for real-time selective parallel manipulation of biological droplet arrays

Tianyi Wang, Shizheng Zhou, Xuekai Liu, Jianghao Zeng, Xiaohan He, Zhihang Yu, Zhiyuan Liu, Xiaomei Liu, Jing Jin, Yonggang Zhu, Liuyong Shi, Hong Yan and Teng Zhou

Lab Chip, 2025, 25, 1416
DOI: 10.1039/D4LC00804A

Miniaturized sample preparation on a digital microfluidics device for sensitive bottom-up microproteomics of mammalian cells using magnetic beads and mass spectrometry-compatible surfactants

Jan Leipert and Andreas Tholey

Lab Chip, 2019, 19, 3490
DOI: 10.1039/C9LC00715F

Portable sample processing for molecular assays: application to Zika virus diagnostics

Tanya Narahari, Joshua Dahmer, Alexandros Sklavounos, Taehyeong Kim, Monika Satkauskas, Ioana Clotea, Man Ho, Julian Lamanna, Christopher Dixon, Darius G. Rackus, Severino Jefferson Ribeiro da Silva, Lindomar Pena, Keith Pardee and Aaron R. Wheeler

Lab Chip, 2022, 22, 1748
DOI: 10.1039/D1LC01068A

Sample pre-concentration on a digital microfluidic platform for rapid AMR detection in urine

Sumit Kalsi, Martha Valiadi, Carrie Turner, Mark Sutton and Hywel Morgan

Lab Chip, 2019, 19, 168
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Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device

Christopher Dixon, Julian Lamanna and Aaron R. Wheeler

Lab Chip, 2020, 20, 1845
DOI: 10.1039/D0LC00302F

On-site low-power sensing nodes for distributed monitoring of heavy metal ions in water

Menglun Zhang, Xi Zhang, Pengfei Niu, Tao Shen, Yi Yuan, Yuantao Bai and Zhilin Wang

Nanotechnology and Precision Engineering, 2021, 4
DOI: 10.1063/10.0003511

Integrated Digital Microfluidic Platform for Colorimetric Sensing of Nitrite

Zhen Gu, Ming-Lei Wu, Bing-Yong Yan, Hui-Feng Wang and Cong Kong

ACS Omega, 2020, 5, 11196
DOI: 10.1021/acsomega.0c01274

Droplet Handling for Chemical Reactors Using a Digital Microfluidic Device

Hirotada Hirama, Satoshi Yoshii, Yusuke Komazaki, Shinya Kano, Toru Torii and Harutaka Mekaru

Chemistry Letters, 2021, 50, 213
DOI: 10.1246/cl.200654

Materials with Tunable Optical Properties for Wearable Epidermal Sensing in Health Monitoring

Fei Han, Tiansong Wang, Guozhen Liu, Hao Liu, Xueyong Xie, Zhao Wei, Jing Li, Cheng Jiang, Yuan He and Feng Xu

Advanced Materials, 2022, 34
DOI: 10.1002/adma.202109055

A review of electrochemical sensing in droplet systems: Droplet and digital microfluidics

Kathy Ly, Aaliya Pathan and Darius G. Rackus

Analytica Chimica Acta, 2025, 1347, 343744
DOI: 10.1016/j.aca.2025.343744

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

Rui Vitorino, Sofia Guedes, João Pinto da Costa and Václav Kašička

Nanomaterials, 2021, 11, 1118
DOI: 10.3390/nano11051118

BaTiO₃/ Teflon Nanocomposite Ferroelectric Thin Films for Low Voltage Electrowetting Systems

Wei Qiang Wang, Jia Qi Niu and Yan Su

SSP, 2018, 281, 616
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Determination of blood lithium-ion concentration using digital microfluidic whole-blood separation and preloaded paper sensors

Takeshi Komatsu, Manabu Tokeshi and Shih-Kang Fan

Biosensors and Bioelectronics, 2022, 195, 113631
DOI: 10.1016/j.bios.2021.113631

Characterization of electrowetting, contact angle hysteresis, and adhesion on digital microfluidic devices with inkjet-printed electrodes

Kimberly A. Bernetski, Marcette Greyson, Kara L. Maki and Michael J. Schertzer

Microfluid Nanofluid, 2018, 22
DOI: 10.1007/s10404-018-2119-4

“Plug-n-Play” Sensing with Digital Microfluidics

Richard P. S. de Campos, Darius G. Rackus, Roger Shih, Chen Zhao, Xinyu Liu and Aaron R. Wheeler

Anal. Chem., 2019, 91, 2506
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Low-Cost Microfluidic Systems for Detection of Neglected Tropical Diseases

Kemilly M.P. Pinheiro, Bárbara G.S. Guinati, Nikaele S. Moreira and Wendell K.T. Coltro

Annual Rev. Anal. Chem., 2023, 16, 117
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Micropumps and biomedical applications – A review

Yao-Nan Wang and Lung-Ming Fu

Microelectronic Engineering, 2018, 195, 121
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Amplification of Femtograms of Bacterial DNA Within 3 h Using a Digital Microfluidics Platform for MinION Sequencing

Yuguang Liu, Patricio Jeraldo, Helena Mendes-Soares, Thao Masters, Abigail E. Asangba, Heidi Nelson, Robin Patel, Nicholas Chia and Marina Walther-Antonio

ACS Omega, 2021, 6, 25642
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A digital microfluidic system for serological immunoassays in remote settings

Alphonsus H. C. Ng, Ryan Fobel, Christian Fobel, Julian Lamanna, Darius G. Rackus, Aimee Summers, Christopher Dixon, Michael D. M. Dryden, Charis Lam, Man Ho, Nooman S. Mufti, Victor Lee, Mohd Afiq Mohd Asri, Edward A. Sykes, M. Dean Chamberlain, Rachael Joseph, Maurice Ope, Heather M. Scobie, Alaine Knipes, Paul A. Rota, Nina Marano, Paul M. Chege, Mary Njuguna, Rosemary Nzunza, Ngina Kisangau, John Kiogora, Michael Karuingi, John Wagacha Burton, Peter Borus, Eugene Lam and Aaron R. Wheeler

Sci. Transl. Med., 2018, 10
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Nucleic acid analysis on electrowetting-based digital microfluidics

Ren Shen, A'man Lv, Shuhong Yi, Ping Wang, Pui-In Mak, Rui P. Martins and Yanwei Jia

TrAC Trends in Analytical Chemistry, 2023, 158, 116826
DOI: 10.1016/j.trac.2022.116826

Determination of Ascorbic Acid in Commercial Tablets Using Pencil Drawn Electrochemical Paper-based Analytical Devices

Virgilio X. G. Oliveira, Anderson A. Dias, Leandro L. Carvalho, Thiago M. G. Cardoso, Flavio Colmati and Wendell K. T. Coltro

ANAL. SCI., 2018, 34, 91
DOI: 10.2116/analsci.34.91

A fucosyltransferase inhibition assay using image-analysis and digital microfluidics

Laura M. Y. Leclerc, Guy Soffer, David H. Kwan and Steve C. C. Shih

Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5088517

Digital Microfluidic Device for Mixing Organic Droplets

Hirotada Hirama, Takahiro Iida, Yusuke Komazaki, Toru Torii and Harutaka Mekaru

Chem. Lett., 2020, 49, 284
DOI: 10.1246/cl.190941

Design Principles for Enhancing Sensitivity in Paper-Based Diagnostics via Large-Volume Processing

Eric A. Miller, Yara Jabbour Al Maalouf and Hadley D. Sikes

Anal. Chem., 2018, 90, 9472
DOI: 10.1021/acs.analchem.8b02113

Digital Microfluidic Thermal Control Chip-Based Multichannel Immunosensor for Noninvasively Detecting Acute Myocardial Infarction

Jienan Shen, Liyuan Zhang, Junjie Yuan, Yongsheng Zhu, Hao Cheng, Yibo Zeng, Jiaqin Wang, Xueqiu You, Chaoyong Yang, Xiangmeng Qu and Hong Chen

Anal. Chem., 2021, 93, 15033
DOI: 10.1021/acs.analchem.1c02758

Systematic Review: Microfluidics and Plasmodium

Nicolas Thorne, Luis Flores-Olazo, Rocío Egoávil-Espejo, Emir A. Vela, Julien Noel, Julio Valdivia-Silva and Danny van Noort

Micromachines, 2021, 12, 1245
DOI: 10.3390/mi12101245