Issue 66, 2024

Viewing 3D spatial biology with highly-multiplexed Raman imaging: from spectroscopy to biotechnology

Abstract

Understansding complex biological systems requires the simultaneous characterization of a large number of interacting components in their native 3D environment with high spatial resolution. Highly-multiplexed Raman imaging is an emerging general strategy for detecting biomarkers with scalable multiplexity and ultra-sensitivity based on a series of stimulated Raman scattering (SRS) techniques. Here we review recent advances in highly-multiplexed Raman imaging and how they contribute to the technological revolution in 3D spatial biology, focusing on the developmental pathway from spectroscopy study to biotechnology invention. We envision highly-multiplexed Raman imaging is taking off, which will greatly facilitate our understanding in biological and medical research fields.

Graphical abstract: Viewing 3D spatial biology with highly-multiplexed Raman imaging: from spectroscopy to biotechnology

Article information

Article type
Feature Article
Submitted
13 5月 2024
Accepted
08 7月 2024
First published
10 7月 2024

Chem. Commun., 2024,60, 8658-8669

Viewing 3D spatial biology with highly-multiplexed Raman imaging: from spectroscopy to biotechnology

Y. Li, Y. Sun and L. Shi, Chem. Commun., 2024, 60, 8658 DOI: 10.1039/D4CC02319F

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