Issue 25, 2023

Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

Abstract

A photoacoustic imaging (Au@PDA-WL NPs) probe was successfully prepared for monitoring the early degeneration of articular cartilage. WYRGRL immobilized on the surface of Au@PDA NPs could target the collagen II peptide, which is expressed on chondrocytes in vivo and in vitro, and the enrichment of this nano-probe on cartilage tissue further resulted in the localized plasmon resonance coupling effect, inducing an enhancement in photothermal conversion capacity after the formation of aggregates. Besides, the catechol structure in the PDA shell could eliminate ROS to effectively delay the development of osteoarthrosis.

Graphical abstract: Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

Article information

Article type
Paper
Submitted
06 4月 2023
Accepted
13 5月 2023
First published
18 5月 2023

J. Mater. Chem. B, 2023,11, 5777-5785

Early diagnosis and treatment of osteoarthritis with a Au@PDA-WL NP nano-probe by photoacoustic imaging

J. Shen, W. Shi, G. Liu, W. Zhuang, K. Wang, Y. Wang, K. Shou, W. Wu, X. Liu, Q. Fan and L. Zhang, J. Mater. Chem. B, 2023, 11, 5777 DOI: 10.1039/D3TB00760J

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