Issue 16, 2021

Two polymorphs of remdesivir: crystal structure, solubility, and pharmacokinetic study

Abstract

Two polymorphic phases of the antiviral drug remdesivir (RDV), namely RDV-I and RDV-II are prepared and structurally characterized by single-crystal X-ray diffraction. Both RDV-I and RDV-II are solvent-free but exhibit different packing patterns in their crystals. RDV-I and RDV-II feature different pharmacokinetics, as revealed by in vitro and in vivo studies. This work highlights the significance of remdesivir drug formulations on the pharmacokinetics and ultimately patient outcome when combating the coronavirus disease 2019 (Covid-19).

Graphical abstract: Two polymorphs of remdesivir: crystal structure, solubility, and pharmacokinetic study

Supplementary files

Article information

Article type
Communication
Submitted
04 2月 2021
Accepted
30 3月 2021
First published
01 4月 2021

CrystEngComm, 2021,23, 2923-2927

Two polymorphs of remdesivir: crystal structure, solubility, and pharmacokinetic study

K. Yu, S. Chen, C. Amgoth, G. Tang, H. Bai and X. Hu, CrystEngComm, 2021, 23, 2923 DOI: 10.1039/D1CE00175B

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