Issue 12, 2020

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Abstract

T cell-based cancer immunotherapy has achieved great success in the clinic; however, only a small fraction of patients respond to this therapy. Strategies to specifically and safely augment anticancer activity through controlled delivery of T cell supporting factors or drugs for combination therapy remain of high interest. Here, we devised a T cell force-responsive system for selective delivery of anticancer drugs using a mesoporous silica microparticle capped with a DNA force sensor. Upon T cell receptor (TCR) triggering, T cells exerted synaptic forces, a unique biophysical stimulus, to rupture the force-sensitive DNA gatekeepers on the mesopores leading to rapid drug release. Our results demonstrated that this cellular force-responsive system specifically released anticancer drugs in a T cell force-dependent manner and significantly enhanced cancer cell killing in vitro and in vivo. This work opens a new horizon toward designing next-generation drug delivery systems in response to signaling-specific cellular forces.

Graphical abstract: T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

Supplementary files

Article information

Article type
Communication
Submitted
09 8月 2020
Accepted
21 10月 2020
First published
22 10月 2020

Mater. Horiz., 2020,7, 3196-3200

T cell force-responsive delivery of anticancer drugs using mesoporous silica microparticles

K. Lei and L. Tang, Mater. Horiz., 2020, 7, 3196 DOI: 10.1039/D0MH01285H

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