Issue 6, 2019

Low fouling strategies for electrochemical biosensors targeting disease biomarkers

Abstract

Over the past few years, different biomarkers related to various disease states have been identified, and the assay of these disease biomarkers, which can reveal the health status and stages of diseases, has received increasing attention. A broad range of analytical techniques have been applied to the detection of these biomarkers, with electrochemical analysis becoming one of the most promising approaches due to high sensitivity, accuracy, wide measurement range and low-cost and portable instrumentation requirements. However, one of the biggest challenges in this field relates to the operation of electrochemical sensors in biological media, as biofouling deleteriously affects the functioning of the electrochemical sensing interface when exposed to biological fluid. In this mini review, recent trends in the development of low fouling electrochemical biosensors based on different antifouling materials are summarized and discussed. Also, an outlook on the opportunities and challenges with regard to future development of low fouling electrochemical biosensors capable of assaying biomarkers in clinical samples is presented.

Graphical abstract: Low fouling strategies for electrochemical biosensors targeting disease biomarkers

Article information

Article type
Minireview
Submitted
07 12月 2018
Accepted
07 1月 2019
First published
07 1月 2019

Anal. Methods, 2019,11, 702-711

Low fouling strategies for electrochemical biosensors targeting disease biomarkers

N. Liu, Z. Xu, A. Morrin and X. Luo, Anal. Methods, 2019, 11, 702 DOI: 10.1039/C8AY02674B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements