Issue 14, 2017

Droplet control technologies for microfluidic high throughput screening (μHTS)

Abstract

The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of fluids used in these studies. Moreover, it significantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices. Since these systems are enclosed and usually planar, even some of the straightforward methods used in traditional HTS such as pipetting and reading can prove challenging to replicate in microfluidic high throughput screening (μHTS). We critically review the technologies developed for this purpose in depth, describing the underlying physics and discussing the future outlooks.

Graphical abstract: Droplet control technologies for microfluidic high throughput screening (μHTS)

Supplementary files

Article information

Article type
Critical Review
Submitted
02 1月 2017
Accepted
08 6月 2017
First published
09 6月 2017

Lab Chip, 2017,17, 2372-2394

Droplet control technologies for microfluidic high throughput screening (μHTS)

M. Sesen, T. Alan and A. Neild, Lab Chip, 2017, 17, 2372 DOI: 10.1039/C7LC00005G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements