Issue 3, 2015

Electrochemical evaluation of a boron-doped diamond electrode for simultaneous determination of an antihypertensive ternary mixture of amlodipine, hydrochlorothiazide and valsartan in pharmaceuticals

Abstract

The simultaneous voltammetric determination of a ternary mixture containing antihypertensive drugs amlodipine (AML), hydrochlorothiazide (HCTZ) and valsartan (VAL) by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode is reported for the first time. Three very well-resolved and reproducible oxidative processes of AML, HCTZ and VAL were found at 0.781 V, 1.14 V and 1.41 V, respectively, in Britton–Robinson buffer solution (pH 5.0). The linearity ranges were 4.9 × 10−7–7.2 × 10−6 mol L−1, 2.9 × 10−6–4.5 × 10−5 mol L−1, and 9.7 × 10−6–1.3 × 10−4 mol L−1 for AML, HCTZ and VAL, with detection limits of 2.3 × 10−7 mol L−1, 7.5 × 10−7 mol L−1, and 6.2 × 10−6 mol L−1, respectively. The proposed method was successfully applied to the simultaneous analysis of these antihypertensive drugs in their combined pharmaceutical tablets available in the market.

Graphical abstract: Electrochemical evaluation of a boron-doped diamond electrode for simultaneous determination of an antihypertensive ternary mixture of amlodipine, hydrochlorothiazide and valsartan in pharmaceuticals

Article information

Article type
Paper
Submitted
22 10月 2014
Accepted
03 12月 2014
First published
03 12月 2014

Anal. Methods, 2015,7, 1053-1060

Electrochemical evaluation of a boron-doped diamond electrode for simultaneous determination of an antihypertensive ternary mixture of amlodipine, hydrochlorothiazide and valsartan in pharmaceuticals

G. R. Mansano, A. P. Pires Eisele and E. R. Sartori, Anal. Methods, 2015, 7, 1053 DOI: 10.1039/C4AY02511C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements