Issue 21, 2024

Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(ii)/chiral norbornene cooperative catalysis

Abstract

An efficient protocol for the asymmetric synthesis of fluorenols has been developed through an enantioconvergent process enabled by Pd(II)/chiral norbornene cooperative catalysis. This approach allows facile access to diverse functionalized chiral fluorenols with constantly excellent enantioselectivities, applying readily available racemic secondary ortho-bromobenzyl alcohols and aryl iodides as the starting materials.

Graphical abstract: Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(ii)/chiral norbornene cooperative catalysis

Supplementary files

Article information

Article type
Edge Article
Submitted
12 2月 2024
Accepted
18 4月 2024
First published
25 4月 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2024,15, 7975-7981

Enantioconvergent synthesis of chiral fluorenols from racemic secondary alcohols via Pd(II)/chiral norbornene cooperative catalysis

B. Ding, Q. Xue, H. Wei, J. Chen, Z. Liu, H. Cheng, H. Cong, J. Tang and Q. Zhou, Chem. Sci., 2024, 15, 7975 DOI: 10.1039/D4SC01004C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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