Issue 12, 2024

Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants

Abstract

19F magnetic resonance (19F MR) tracers stand out for their wide range of applications in experimental and clinical medicine, as they can be precisely located in living tissues with negligible fluorine background. This contribution demonstrates the long-term dissolution of multiresponsive fluorinated implants designed for prolonged release. Implants were detected for 14 (intramuscular injection) and 20 (subcutaneous injection) months by 19F MR at 4.7 T, showing favorable MR relaxation times, biochemical stability, biological compatibility and slow, long-term dissolution. Thus, polymeric implants may become a platform for long-term local theranostics.

Graphical abstract: Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants

Supplementary files

Article information

Article type
Paper
Submitted
14 3月 2024
Accepted
28 3月 2024
First published
08 4月 2024
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2024,6, 3041-3051

Long-term in vivo dissolution of thermo- and pH-responsive, 19F magnetic resonance-traceable and injectable polymer implants

N. Jirát-Ziółkowska, M. Vít, O. Groborz, K. Kolouchová, D. Červený, O. Sedláček and D. Jirák, Nanoscale Adv., 2024, 6, 3041 DOI: 10.1039/D4NA00212A

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