Issue 5, 2024

Reductive amination of carboxylic acids under H2 using a heterogeneous Pt–Mo catalyst

Abstract

Reductive amination of carboxylic acids is a green and sustainable method for alkylamine synthesis because carboxylic acids are abundant and accessible carbon sources. Herein, we present an aluminum oxide-supported platinum–molybdenum (Pt–Mo/γ-Al2O3) catalyst that enables mild and selective reductive amination of carboxylic acids under H2. Pt–Mo/γ-Al2O3 exhibited high performance even under ambient H2 pressure. A broad range of carboxylic acids and amines were transformed into alkylamines with good functional group tolerance. Notably, the amination of biomass-derived fatty acids led to the successful formation of the corresponding fatty amines. The catalyst was reusable at least four times without any significant loss in activity. The development of highly active heterogeneous Pt–Mo catalysts with wide applicability and reusability will significantly contribute to sustainable alkylamine production.

Graphical abstract: Reductive amination of carboxylic acids under H2 using a heterogeneous Pt–Mo catalyst

Supplementary files

Article information

Article type
Paper
Submitted
16 6月 2023
Accepted
20 12月 2023
First published
22 12月 2023
This article is Open Access
Creative Commons BY-NC license

Green Chem., 2024,26, 2571-2576

Reductive amination of carboxylic acids under H2 using a heterogeneous Pt–Mo catalyst

K. Sakoda, S. Yamaguchi, K. Honjo, Y. Kitagawa, T. Mitsudome and T. Mizugaki, Green Chem., 2024, 26, 2571 DOI: 10.1039/D3GC02155F

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