Issue 39, 2023

Dual ligand-assisted assembly of metal–organic frameworks on upconversion nanoparticles for NIR photodynamic therapy against hypoxic tumors

Abstract

The hypoxic nature of tumor microenvironments significantly impedes the effectiveness of photodynamic therapy (PDT). To address this challenge, we constructed a pioneering nanohybrid by integrating upconversion nanoparticles (UCNPs) and metal–organic frameworks (MOFs) through a dual-ligand-assisted assembly approach. We functionalized UCNPs with polyvinyl pyrrolidone (PVP) and branched polyethylenimine (PEI), enabling the in situ growth of MOFs on multiple UCNP-conjugates. This nanohybrid, termed UCM, possesses a unique heterogeneous structure that facilitates effective energy transfer from UCNPs to MOFs, enhancing NIR-activated PDT. A distinguishing feature of UCMs is biocatalytically active MOFs, which provide them with a peroxidase-like capability. This characteristic allows UCMs to utilize the excess H2O2 in the tumor microenvironment, ensuring continuous oxygen production essential for type II PDT. Our research indicates that UCMs not only amplify the efficacy of PDT but also address the therapeutic challenges in hypoxic tumor microenvironments by supplying in situ oxygen.

Graphical abstract: Dual ligand-assisted assembly of metal–organic frameworks on upconversion nanoparticles for NIR photodynamic therapy against hypoxic tumors

Supplementary files

Article information

Article type
Paper
Submitted
20 6月 2023
Accepted
07 9月 2023
First published
22 9月 2023

J. Mater. Chem. B, 2023,11, 9516-9524

Dual ligand-assisted assembly of metal–organic frameworks on upconversion nanoparticles for NIR photodynamic therapy against hypoxic tumors

X. Zhang, J. Cui, J. Liu, X. Chen, M. Chen and J. Wang, J. Mater. Chem. B, 2023, 11, 9516 DOI: 10.1039/D3TB01398G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements