Issue 20, 2023

Water-soluble polymer brush-substituted squaraine NIR-II dye for efficient photothermal therapy

Abstract

Near-infrared II (NIR-II, 1000–1700 nm) fluorescence imaging has the advantages of low light scattering and weak biological autofluorescence compared with conventional NIR (600–900 nm) fluorescence imaging and can obtain a high signal-to-noise ratio in deeper biological tissues, as well as micron-level high resolution. A great deal of effort has been directed toward the construction of conjugated polymers for effective NIR-triggered fluorescence imaging (FI) and photothermal therapy (PTT) combined therapy. However, NIR-II fluorescent materials are mainly nanoparticles prepared by coprecipitation methods, and water-soluble NIR-II materials need to be further developed. In this paper, we synthesized novel water-soluble squaric acid nanoparticles (SQ-POEGMA) with low toxicity and excellent photostability by attaching a water-soluble oligomer (POEGMA) to the small molecule squaric acid through a click chemistry reaction. The photothermal conversion efficiency of SQ-POEGMA is 33% in vitro, which can effectively inhibit the growth of cancer cells with 94% tumor inhibition rate in vivo under 808 nm laser irradiation, while no appreciable side effects were observed.

Graphical abstract: Water-soluble polymer brush-substituted squaraine NIR-II dye for efficient photothermal therapy

Supplementary files

Article information

Article type
Communication
Submitted
09 3月 2023
Accepted
11 4月 2023
First published
26 4月 2023

J. Mater. Chem. B, 2023,11, 4389-4395

Water-soluble polymer brush-substituted squaraine NIR-II dye for efficient photothermal therapy

X. Li, S. Guo, W. Deng, S. Wu, P. Sun and Y. Liu, J. Mater. Chem. B, 2023, 11, 4389 DOI: 10.1039/D3TB00510K

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