Issue 33, 2023

Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

Abstract

A generic strategy to construct virus protein-based hybrid nanomaterials is reported by using a macromolecular glue inspired by mussel adhesion. Commercially available poly(isobutylene-alt-maleic anhydride) (PiBMA) modified with dopamine (PiBMAD) is designed as this macromolecular glue, which serves as a universal adhesive material for the construction of multicomponent hybrid nanomaterials. As a proof of concept, gold nanorods (AuNRs) and single-walled carbon nanotubes (SWCNTs) are initially coated with PiBMAD. Subsequently, viral capsid proteins from the Cowpea Chlorotic Mottle Virus (CCMV) assemble around the nano-objects templated by the negative charges of the glue. With virtually unchanged properties of the rods and tubes, the hybrid materials might show improved biocompatibility and can be used in future studies toward cell uptake and delivery.

Graphical abstract: Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

Supplementary files

Article information

Article type
Paper
Submitted
09 12月 2022
Accepted
06 6月 2023
First published
06 6月 2023
This article is Open Access
Creative Commons BY license

J. Mater. Chem. B, 2023,11, 7933-7941

Construction of viral protein-based hybrid nanomaterials mediated by a macromolecular glue

S. Cao, S. Peeters, S. Michel-Souzy, N. Hamelmann, J. M. J. Paulusse, L. Yang and J. J. L. M. Cornelissen, J. Mater. Chem. B, 2023, 11, 7933 DOI: 10.1039/D2TB02688K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements