Issue 2, 2023

Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

Abstract

Bioorthogonal chemistry enables researchers to manipulate bioactive molecules in living systems. These highly selective and biocompatible reactions can be carried out in various complex environments. Over the past two decades, a considerable number of strides have been made to expand the capacities of bioorthogonal chemistry coupled with the aim to fine-tune present reactions for specific applications. The good points of bioorthogonal chemistry have pushed material chemists to integrate bioorthogonal chemistry with nanotechnologies to broaden the biological applications of nanomaterials. Notably, bioorthogonal nanotechnologies fundamentally rely on, more than half, according to our investigation, tetrazine bioorthogonal chemistry (TBC) to function as bioorthogonal handles to react with target agents owing to the extremely rapid kinetics and high selectivities of TBC. Its utilization in combination with nanotechnologies has led to developments in various areas of biomedicine, such as in situ drug activation and targeted delivery, bioimaging and biosensing, and the understanding of cell–biomolecule interactions. Given the fantastic past achievements and the rapid developments in tetrazine bioorthogonal technologies, the future is certainly very bright.

Graphical abstract: Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

Article information

Article type
Minireview
Submitted
30 10月 2022
Accepted
30 11月 2022
First published
07 12月 2022

Nanoscale, 2023,15, 461-469

Tetrazine bioorthogonal chemistry makes nanotechnology a powerful toolbox for biological applications

R. Zhang, J. Gao, G. Zhao, L. Zhou, F. Kong, T. Jiang and H. Jiang, Nanoscale, 2023, 15, 461 DOI: 10.1039/D2NR06056F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements