Issue 15, 2023

Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

Abstract

Gene therapy is a promising approach for the treatment of many diseases. However, the effective delivery of the cargo without degradation in vivo is one of the major hurdles. With the advent of lipid nanoparticles (LNPs) and cell-derived nanovesicles (CDNs), gene delivery holds a very promising future. The targeting of these nanosystems is a prerequisite for effective transfection with minimal side-effects. In this review, we highlight the emerging strategies utilized for the effective targeting of LNPs and CDNs, and we summarize the preparation methodologies for LNPs and CDNs. We have also highlighted the non-ligand targeting of LNPs toward certain organs based on their composition. It is highly expected that continuing the developments in the targeting approaches of LNPs and CDNs for the delivery system will further promote them in clinical translation.

Graphical abstract: Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

Article information

Article type
Review Article
Submitted
27 3月 2023
Accepted
10 6月 2023
First published
07 7月 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 3834-3856

Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

D. Lee, S. Amirthalingam, C. Lee, A. K. Rajendran, Y. Ahn and N. S. Hwang, Nanoscale Adv., 2023, 5, 3834 DOI: 10.1039/D3NA00198A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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