Issue 28, 2023

Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

Abstract

Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT.

Graphical abstract: Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

Supplementary files

Article information

Article type
Communication
Submitted
26 12月 2022
Accepted
09 3月 2023
First published
20 3月 2023

Chem. Commun., 2023,59, 4181-4184

Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs

X. Li, W. Liu, X. Zheng, M. Jiang, Y. Guo, J. Sha, J. Wu, H. Ren, H. Gao, S. Wang and P. Wang, Chem. Commun., 2023, 59, 4181 DOI: 10.1039/D2CC07025A

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