Issue 34, 2023

Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy

Abstract

A multifunctional undecapeptide, YYDPLGLADYY, was designed and synthesized for the photowrapping of silica-coated gold nanorods. The obtained nanocapsules, bearing a well-defined core–shell structure, were able to encapsulate a therapeutic drug, respond to an MMP-upregulated tumor microenvironment, and achieve NIR-triggered anticancer chemo-photothermal therapy with favorable efficacy.

Graphical abstract: Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy

Supplementary files

Article information

Article type
Communication
Submitted
08 12月 2022
Accepted
23 3月 2023
First published
27 3月 2023

Chem. Commun., 2023,59, 5059-5062

Peptide photowrapping of gold-silica nanocomposites for constructing MMP-responsive drug capsules for chemo-photothermal therapy

H. Liu, S. He, L. Niu, X. Gao, K. Feng, S. Yang, J. Shao, W. Zhao, N. Xie and Q. Yang, Chem. Commun., 2023, 59, 5059 DOI: 10.1039/D2CC06696C

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