Issue 37, 2022

Biosafety evaluation of dual-responsive neutrobots

Abstract

The toxicity effects of paclitaxel (PTX)-loaded magnetic neutrophil-hybrid swimming microrobots (“neutrobots”) in vivo were assessed after intravenous administration to mice. The mice after 72 hours exhibited minimal immunotoxicity and liver and kidney toxicity at an administration dose of 3 × 106 PTX-loaded neutrobots. The minor toxicity of drug-loaded neutrobots holds considerable promise for biomedical applications.

Graphical abstract: Biosafety evaluation of dual-responsive neutrobots

Article information

Article type
Paper
Submitted
29 4月 2022
Accepted
08 6月 2022
First published
16 6月 2022

J. Mater. Chem. B, 2022,10, 7556-7562

Biosafety evaluation of dual-responsive neutrobots

H. Zhang, L. Wang, Z. Li, Y. Ji, Z. Wu and Q. He, J. Mater. Chem. B, 2022, 10, 7556 DOI: 10.1039/D2TB00938B

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