Issue 8, 2022

Cellular nanointerface of vertical nanostructure arrays and its applications

Abstract

Vertically standing nanostructures with various morphologies have been developed with the emergence of the micro-/nanofabrication technology. When cells are cultured on them, various bio–nano interfaces between cells and vertical nanostructures would impact the cellular activities, depending on the shape, density, and height of nanostructures. Many cellular pathway activation processes involving a series of intracellular molecules (proteins, RNA, DNA, enzymes, etc.) would be triggered by the cell morphological changes induced by nanostructures, affecting the cell proliferation, apoptosis, differentiation, immune activation, cell adhesion, cell migration, and other behaviors. In addition, the highly localized cellular nanointerface enhances coupled stimulation on cells. Therefore, understanding the mechanism of the cellular nanointerface can not only provide innovative tools for regulating specific cell functions but also offers new aspects to understand the fundamental cellular activities that could facilitate the precise monitoring and treatment of diseases in the future. This review mainly describes the fabrication technology of vertical nanostructures, analyzing the formation of cellular nanointerfaces and the effects of cellular nanointerfaces on cells' fates and functions. At last, the applications of cellular nanointerfaces based on various nanostructures are summarized.

Graphical abstract: Cellular nanointerface of vertical nanostructure arrays and its applications

Article information

Article type
Review Article
Submitted
28 10月 2021
Accepted
28 11月 2021
First published
21 2月 2022
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2022,4, 1844-1867

Cellular nanointerface of vertical nanostructure arrays and its applications

A. Zhang, J. Fang, X. Li, J. Wang, M. Chen, H. Chen, G. He and X. Xie, Nanoscale Adv., 2022, 4, 1844 DOI: 10.1039/D1NA00775K

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