Issue 8, 2022

Ultra-sensitive speciation analysis of inorganic platinum-chloride complexes in platinum-based drugs by HPLC-ICP-MS

Abstract

This work establishes a hyphenated methodology coupling HPLC with ICP-MS for the determination of platinum chloride complexes as synthetic impurities of platinum-based drugs for the first time. The separation of inorganic platinum-chloride complexes was accomplished in less than 3 min on an anion exchange column with a mobile phase containing 2 mmol L−1 (v : v) HCl. The detection limits were found to be 0.2 μg L−1 and 0.3 μg L−1 for potassium hexachloroplatinate (K2PtCl6) and potassium chloroplatinate (K2PtCl4), respectively. Method precision and accuracy were satisfactory at <3% relative standard deviations (RSDs) for 10 μg L−1 of K2PtCl6 and K2PtCl4, and >90% recoveries for real samples. The method has the advantages of simplicity, rapidity and sensitivity, and provides a basis for quality control of trace impurities in the production process of platinum-based drugs.

Graphical abstract: Ultra-sensitive speciation analysis of inorganic platinum-chloride complexes in platinum-based drugs by HPLC-ICP-MS

Supplementary files

Article information

Article type
Paper
Submitted
12 4月 2022
Accepted
15 6月 2022
First published
17 6月 2022

J. Anal. At. Spectrom., 2022,37, 1652-1657

Ultra-sensitive speciation analysis of inorganic platinum-chloride complexes in platinum-based drugs by HPLC-ICP-MS

Z. Yao, B. Li, C. Li, B. Wang, M. Zhao and Z. Ma, J. Anal. At. Spectrom., 2022, 37, 1652 DOI: 10.1039/D2JA00126H

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