Issue 27, 2021

Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

Abstract

Carbon monoxide (CO) is being increasingly appreciated as a major physiological gasomediator and plays significant roles in different biological activities. However, site-specific delivery of this toxic gas faces major difficulties in the healthcare system in terms of unavailability of appropriate equipment for delivery. A well-known and most studied carbon monoxide releasing molecule (CORM) is tricarbonyldichlororuthenium(II) dimer (Ru2Cl4(CO)6). However, its use as a therapeutic agent is restricted due to its poor water solubility and a short half-life. In order to solve this issues we have designed and synthesized a water-soluble methionine (methionine methacryloyloxyethyl ester (METMA)) and poly(ethylene glycol methyl ether methacrylate) containing block-copolymer via reversible addition–fragmentation chain transfer (RAFT) polymerization and attached the CORM in the methionine side chain units. Inductively coupled plasma optical emission spectrometry (ICP-OES) and FT-IR confirms the presence of CORM molecule into the polymer. The time-dependent CO release from CORM conjugated block-copolymer was investigated by a myoglobin assay. This CORM conjugated block-copolymer slowly and spontaneously released CO with sustained-release kinetics. Moreover, this CO-releasing polymer was able to prevent biofilm formation against Pseudomonas aeruginosa.

Graphical abstract: Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

Supplementary files

Article information

Article type
Paper
Submitted
22 4月 2021
Accepted
21 6月 2021
First published
23 6月 2021

Polym. Chem., 2021,12, 3968-3975

Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

B. Maiti, G. Ng, A. Abramov, C. Boyer and D. D. Díaz, Polym. Chem., 2021, 12, 3968 DOI: 10.1039/D1PY00546D

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